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How diet affects tumors
La Spezia, with the Parco delle Mura, the redevelopment of a historical and architectural path starts
ÖFB Cup: WAC continues to struggle at the peat festival
By playing appeasement, Erdogan and the West are avoiding the crisis
Interview: Identifying talent at Nasa using data science
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Anti-Covid-19 pill: France has ordered 50,000 doses manufactured by the American Merck
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Covid: vaccinations and infections ? how common are neurological complications?
Dutch justice orders return of Crimean archaeological treasures to Ukraine

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                    [title] => How diet affects tumors
                    [link] => https://bofads.com/how-diet-affects-tumors/
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                            [creator] => Tony Grantly
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                    [pubdate] => Tue, 26 Oct 2021 14:54:51 +0000
                    [category] => Health And Sciencediettumors
                    [guid] => https://bofads.com/?p=3768
                    [description] => Journal Reference: Evan C. Lien, Anna M. Westermark, Yin Zhang, Chen Yuan, Zhaoqi Li, Allison N. Lau, Kiera M. Sapp, Brian M. Wolpin, Matthew G. Vander Heiden. Low glycaemic diets alter lipid metabolism to influence tumour growth. Nature, 2021; DOI: 10.1038/s41586-021-04049-2 The study examined the effects of a calorically restricted diet and a ketogenic diet ... Read more
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Journal Reference:

  1. Evan C. Lien, Anna M. Westermark, Yin Zhang, Chen Yuan, Zhaoqi Li, Allison N. Lau, Kiera M. Sapp, Brian M. Wolpin, Matthew G. Vander Heiden. Low glycaemic diets alter lipid metabolism to influence tumour growth. Nature, 2021; DOI: 10.1038/s41586-021-04049-2

The study examined the effects of a calorically restricted diet and a ketogenic diet in mice with pancreatic tumors. While both of these diets reduce the amount of sugar available to tumors, the researchers found that only the calorically restricted diet reduced the availability of fatty acids, and this was linked to a slowdown in tumor growth.

The findings do not suggest that cancer patients should try to follow either of these diets, the researchers say. Instead, they believe the findings warrant further study to determine how dietary interventions might be combined with existing or emerging drugs to help patients with cancer.

?There?s a lot of evidence that diet can affect how fast your cancer progresses, but this is not a cure,? says Matthew Vander Heiden, director of MIT?s Koch Institute for Integrative Cancer Research and the senior author of the study. ?While the findings are provocative, further study is needed, and individual patients should talk to their doctor about the right dietary interventions for their cancer.?

MIT postdoc Evan Lien is the lead author of the paper, which appears today in Nature.

Metabolic mechanism

Vander Heiden, who is also a medical oncologist at Dana-Farber Cancer Institute, says his patients often ask him about the potential benefits of various diets, but there is not enough scientific evidence available to offer any definitive advice. Many of the dietary questions that patients have focus on either a calorie-restricted diet, which reduces calorie consumption by 25 to 50 percent, or a ketogenic diet, which is low in carbohydrates and high in fat and protein.

Previous studies have suggested that a calorically restricted diet might slow tumor growth in some contexts, and such a diet has been shown to extend lifespan in mice and many other animal species. A smaller number of studies exploring the effects of a ketogenic diet on cancer have produced inconclusive results.

?A lot of the advice or cultural fads that are out there aren?t necessarily always based on very good science,? Lien says. ?It seemed like there was an opportunity, especially with our understanding of cancer metabolism having evolved so much over the past 10 years or so, that we could take some of the biochemical principles that we?ve learned and apply those concepts to understanding this complex question.?

Cancer cells consume a great deal of glucose, so some scientists had hypothesized that either the ketogenic diet or calorie restriction might slow tumor growth by reducing the amount of glucose available. However, the MIT team?s initial experiments in mice with pancreatic tumors showed that calorie restriction has a much greater effect on tumor growth than the ketogenic diet, so the researchers suspected that glucose levels were not playing a major role in the slowdown.

To dig deeper into the mechanism, the researchers analyzed tumor growth and nutrient concentration in mice with pancreatic tumors, which were fed either a normal, ketogenic, or calorie-restricted diet. In both the ketogenic and calorie-restricted mice, glucose levels went down. In the calorie-restricted mice, lipid levels also went down, but in mice on the ketogenic diet, they went up.

Lipid shortages impair tumor growth because cancer cells need lipids to construct their cell membranes. Normally, when lipids aren?t available in a tissue, cells can make their own. As part of this process, they need to maintain the right balance of saturated and unsaturated fatty acids, which requires an enzyme called stearoyl-CoA desaturase (SCD). This enzyme is responsible for converting saturated fatty acids into unsaturated fatty acids.

Both calorie-restricted and ketogenic diets reduce SCD activity, but mice on the ketogenic diet had lipids available to them from their diet, so they didn?t need to use SCD. Mice on the calorie-restricted diet, however, couldn?t get fatty acids from their diet or produce their own. In these mice, tumor growth slowed significantly, compared to mice on the ketogenic diet.

?Not only does caloric restriction starve tumors of lipids, it also impairs the process that allows them to adapt to it. That combination is really contributing to the inhibition of tumor growth,? Lien says.

Dietary effects

In addition to their mouse research, the researchers also looked at some human data. Working with Brian Wolpin, an oncologist at Dana-Farber Cancer Institute and an author of the paper, the team obtained data from a large cohort study that allowed them to analyze the relationship between dietary patterns and survival times in pancreatic cancer patients. From that study, the researchers found that the type of fat consumed appears to influence how patients on a low-sugar diet fare after a pancreatic cancer diagnosis, although the data are not complete enough to draw any conclusions about the effect of diet, the researchers say.

Although this study showed that calorie restriction has beneficial effects in mice, the researchers say they do not recommend that cancer patients follow a calorie-restricted diet, which is difficult to maintain and can have harmful side effects. However, they believe that cancer cells? dependence on the availability of unsaturated fatty acids could be exploited to develop drugs that might help slow tumor growth.

One possible therapeutic strategy could be inhibition of the SCD enzyme, which would cut off tumor cells? ability to produce unsaturated fatty acids.

?The purpose of these studies isn?t necessarily to recommend a diet, but it?s to really understand the underlying biology,? Lien says. ?They provide some sense of the mechanisms of how these diets work, and that can lead to rational ideas on how we might mimic those situations for cancer therapy.?

The researchers now plan to study how diets with a variety of fat sources ? including plant or animal-based fats with defined differences in saturated, monounsaturated, and polyunsaturated fatty acid content ? alter tumor fatty acid metabolism and the ratio of unsaturated to saturated fatty acids.

The research was funded by the Damon Runyon Cancer Research Foundation, the National Institutes of Health, the Lustgarten Foundation, the Dana-Farber Cancer Institute Hale Family Center for Pancreatic Cancer Research, Stand Up to Cancer, the Pancreatic Cancer Action Network, the Noble Effort Fund, the Wexler Family Fund, Promises for Purple, the Bob Parsons Fund, the Emerald Foundation, the Howard Hughes Medical Institute, the MIT Center for Precision Cancer Medicine, and the Ludwig Center at MIT.

We want to thank the author of this article for this awesome content

How diet affects tumors

) [summary] => Journal Reference: Evan C. Lien, Anna M. Westermark, Yin Zhang, Chen Yuan, Zhaoqi Li, Allison N. Lau, Kiera M. Sapp, Brian M. Wolpin, Matthew G. Vander Heiden. Low glycaemic diets alter lipid metabolism to influence tumour growth. Nature, 2021; DOI: 10.1038/s41586-021-04049-2 The study examined the effects of a calorically restricted diet and a ketogenic diet ... Read more [atom_content] =>

Journal Reference:

  1. Evan C. Lien, Anna M. Westermark, Yin Zhang, Chen Yuan, Zhaoqi Li, Allison N. Lau, Kiera M. Sapp, Brian M. Wolpin, Matthew G. Vander Heiden. Low glycaemic diets alter lipid metabolism to influence tumour growth. Nature, 2021; DOI: 10.1038/s41586-021-04049-2

The study examined the effects of a calorically restricted diet and a ketogenic diet in mice with pancreatic tumors. While both of these diets reduce the amount of sugar available to tumors, the researchers found that only the calorically restricted diet reduced the availability of fatty acids, and this was linked to a slowdown in tumor growth.

The findings do not suggest that cancer patients should try to follow either of these diets, the researchers say. Instead, they believe the findings warrant further study to determine how dietary interventions might be combined with existing or emerging drugs to help patients with cancer.

?There?s a lot of evidence that diet can affect how fast your cancer progresses, but this is not a cure,? says Matthew Vander Heiden, director of MIT?s Koch Institute for Integrative Cancer Research and the senior author of the study. ?While the findings are provocative, further study is needed, and individual patients should talk to their doctor about the right dietary interventions for their cancer.?

MIT postdoc Evan Lien is the lead author of the paper, which appears today in Nature.

Metabolic mechanism

Vander Heiden, who is also a medical oncologist at Dana-Farber Cancer Institute, says his patients often ask him about the potential benefits of various diets, but there is not enough scientific evidence available to offer any definitive advice. Many of the dietary questions that patients have focus on either a calorie-restricted diet, which reduces calorie consumption by 25 to 50 percent, or a ketogenic diet, which is low in carbohydrates and high in fat and protein.

Previous studies have suggested that a calorically restricted diet might slow tumor growth in some contexts, and such a diet has been shown to extend lifespan in mice and many other animal species. A smaller number of studies exploring the effects of a ketogenic diet on cancer have produced inconclusive results.

?A lot of the advice or cultural fads that are out there aren?t necessarily always based on very good science,? Lien says. ?It seemed like there was an opportunity, especially with our understanding of cancer metabolism having evolved so much over the past 10 years or so, that we could take some of the biochemical principles that we?ve learned and apply those concepts to understanding this complex question.?

Cancer cells consume a great deal of glucose, so some scientists had hypothesized that either the ketogenic diet or calorie restriction might slow tumor growth by reducing the amount of glucose available. However, the MIT team?s initial experiments in mice with pancreatic tumors showed that calorie restriction has a much greater effect on tumor growth than the ketogenic diet, so the researchers suspected that glucose levels were not playing a major role in the slowdown.

To dig deeper into the mechanism, the researchers analyzed tumor growth and nutrient concentration in mice with pancreatic tumors, which were fed either a normal, ketogenic, or calorie-restricted diet. In both the ketogenic and calorie-restricted mice, glucose levels went down. In the calorie-restricted mice, lipid levels also went down, but in mice on the ketogenic diet, they went up.

Lipid shortages impair tumor growth because cancer cells need lipids to construct their cell membranes. Normally, when lipids aren?t available in a tissue, cells can make their own. As part of this process, they need to maintain the right balance of saturated and unsaturated fatty acids, which requires an enzyme called stearoyl-CoA desaturase (SCD). This enzyme is responsible for converting saturated fatty acids into unsaturated fatty acids.

Both calorie-restricted and ketogenic diets reduce SCD activity, but mice on the ketogenic diet had lipids available to them from their diet, so they didn?t need to use SCD. Mice on the calorie-restricted diet, however, couldn?t get fatty acids from their diet or produce their own. In these mice, tumor growth slowed significantly, compared to mice on the ketogenic diet.

?Not only does caloric restriction starve tumors of lipids, it also impairs the process that allows them to adapt to it. That combination is really contributing to the inhibition of tumor growth,? Lien says.

Dietary effects

In addition to their mouse research, the researchers also looked at some human data. Working with Brian Wolpin, an oncologist at Dana-Farber Cancer Institute and an author of the paper, the team obtained data from a large cohort study that allowed them to analyze the relationship between dietary patterns and survival times in pancreatic cancer patients. From that study, the researchers found that the type of fat consumed appears to influence how patients on a low-sugar diet fare after a pancreatic cancer diagnosis, although the data are not complete enough to draw any conclusions about the effect of diet, the researchers say.

Although this study showed that calorie restriction has beneficial effects in mice, the researchers say they do not recommend that cancer patients follow a calorie-restricted diet, which is difficult to maintain and can have harmful side effects. However, they believe that cancer cells? dependence on the availability of unsaturated fatty acids could be exploited to develop drugs that might help slow tumor growth.

One possible therapeutic strategy could be inhibition of the SCD enzyme, which would cut off tumor cells? ability to produce unsaturated fatty acids.

?The purpose of these studies isn?t necessarily to recommend a diet, but it?s to really understand the underlying biology,? Lien says. ?They provide some sense of the mechanisms of how these diets work, and that can lead to rational ideas on how we might mimic those situations for cancer therapy.?

The researchers now plan to study how diets with a variety of fat sources ? including plant or animal-based fats with defined differences in saturated, monounsaturated, and polyunsaturated fatty acid content ? alter tumor fatty acid metabolism and the ratio of unsaturated to saturated fatty acids.

The research was funded by the Damon Runyon Cancer Research Foundation, the National Institutes of Health, the Lustgarten Foundation, the Dana-Farber Cancer Institute Hale Family Center for Pancreatic Cancer Research, Stand Up to Cancer, the Pancreatic Cancer Action Network, the Noble Effort Fund, the Wexler Family Fund, Promises for Purple, the Bob Parsons Fund, the Emerald Foundation, the Howard Hughes Medical Institute, the MIT Center for Precision Cancer Medicine, and the Ludwig Center at MIT.

We want to thank the author of this article for this awesome content

How diet affects tumors

[date_timestamp] => 1635260091 ) [1] => Array ( [title] => La Spezia, with the Parco delle Mura, the redevelopment of a historical and architectural path starts [link] => https://bofads.com/la-spezia-with-the-parco-delle-mura-the-redevelopment-of-a-historical-and-architectural-path-starts/ [dc] => Array ( [creator] => Harry World ) [pubdate] => Tue, 26 Oct 2021 14:27:19 +0000 [category] => LifestylearchitecturaldellehistoricalMuraParcoPathredevelopmentSpeziastarts [guid] => https://bofads.com/?p=3764 [description] => It was inaugurated on Saturday 23 October on Park of the Walls, the project of the recovery of the historic walls which is part of a wider project of rediscovery and requalification of the architectural testimonies of the history of Spezzina pre and post Arsenalizia. The works were financed with resources from the Regional Strategic ... Read more [content] => Array ( [encoded] =>

It was inaugurated on Saturday 23 October on Park of the Walls, the project of the recovery of the historic walls which is part of a wider project of rediscovery and requalification of the architectural testimonies of the history of Spezzina pre and post Arsenalizia.

The works were financed with resources from the Regional Strategic Fund and municipal resources for a total of 1 million 500 thousand euros .

“The Parco delle Mura is the first piece of the largest mosaic that is Spezia Forte, the recovery of La Spezia history from the fourteenth to the twentieth century so that the people of La Spezia can regain possession of the places in the heart of our city and become an unprecedented tourist flywheel – declares the Mayor della Spezia Pierluigi Peracchini – the Parco delle Mura winds for 4 km and is a path surrounded by nature that connects the city center with the hilly area: today we inaugurate the first section, but we are already working on the second, with a view to finalize the path to reach the Parco della Rimembranza, whose inauguration is scheduled for next spring.

The Parco delle Mura – continues the Mayor – is beauty to be experienced 24 hours a day, from sunrise to sunset: excursions, romantic walks, Sunday outings, in total safety thanks to video surveillance, at the maximum possible inclusion for people with disabilities, night lighting. A dream of the people of La Spezia that becomes reality thanks to the resources of the Liguria Region which from the very beginning strongly believed in this project ».

«As the Liguria region, through the Regional Strategic Fund, we have gladly financed the redevelopment of an area so important for the city of La Spezia – explained the president of the Liguria region Giovanni Toti -. The Parco delle Mura represents an area of ??great value in the city, both from the point of view of urban and historical greenery, an investment that will allow the city to increase its tourist appeal even more, with a splendid path in the green and a dip in history for its citizens “.

The inauguration of the Parco delle Mura is part of the larger historical project “Spezia Forte” which also includes the Parco della Rimembranza, a Museum dedicated to the Cold War, the restoration of the former convent of the Poor Clares, the recovery of the Quintino Sella anti-aircraft gallery each identified with a specific brand, historical explanatory panels in Italian and English complete with information and QR code. The Parco delle Mura will become a new place for La Spezia people and tourists where, immersed in nature, they can take a dip in the past of our city, admire the breathtaking panorama with unprecedented views and also spend an unforgettable evening with the illuminated walls.

The project of “Redevelopment and recovery of the nineteenth-century walls of La Spezia”, ??has included and involved all those works necessary for the recovery and enhancement of the nineteenth-century walls of La Spezia to make the parallel path accessible to them which, together with the existing historical artifact relating to the so-called security belt, is organically inserted in a compendium that runs for about 4 km and is called “Parco delle mura”. This park is spread over the hilly area of ??La Spezia, embracing the historic nucleus of nineteenth-century expansion and develops in an almost continuous arc in an east-west direction starting from the area behind the Cathedral to the Collina di Gaggiola to the west, including exclusively the areas relating to the paths located outside and above the walls.

Finally, a video surveillance system was created to ensure maximum safety and also discourage phenomena of waste abandonment and a lighting system that will guarantee on the one hand the use of the site even in the evening and on the other will allow a very suggestive view of the walls in evening time from the city.

We would love to give thanks to the writer of this short article for this incredible web content

La Spezia, with the Parco delle Mura, the redevelopment of a historical and architectural path starts

) [summary] => It was inaugurated on Saturday 23 October on Park of the Walls, the project of the recovery of the historic walls which is part of a wider project of rediscovery and requalification of the architectural testimonies of the history of Spezzina pre and post Arsenalizia. The works were financed with resources from the Regional Strategic ... Read more [atom_content] =>

It was inaugurated on Saturday 23 October on Park of the Walls, the project of the recovery of the historic walls which is part of a wider project of rediscovery and requalification of the architectural testimonies of the history of Spezzina pre and post Arsenalizia.

The works were financed with resources from the Regional Strategic Fund and municipal resources for a total of 1 million 500 thousand euros .

“The Parco delle Mura is the first piece of the largest mosaic that is Spezia Forte, the recovery of La Spezia history from the fourteenth to the twentieth century so that the people of La Spezia can regain possession of the places in the heart of our city and become an unprecedented tourist flywheel – declares the Mayor della Spezia Pierluigi Peracchini – the Parco delle Mura winds for 4 km and is a path surrounded by nature that connects the city center with the hilly area: today we inaugurate the first section, but we are already working on the second, with a view to finalize the path to reach the Parco della Rimembranza, whose inauguration is scheduled for next spring.

The Parco delle Mura – continues the Mayor – is beauty to be experienced 24 hours a day, from sunrise to sunset: excursions, romantic walks, Sunday outings, in total safety thanks to video surveillance, at the maximum possible inclusion for people with disabilities, night lighting. A dream of the people of La Spezia that becomes reality thanks to the resources of the Liguria Region which from the very beginning strongly believed in this project ».

«As the Liguria region, through the Regional Strategic Fund, we have gladly financed the redevelopment of an area so important for the city of La Spezia – explained the president of the Liguria region Giovanni Toti -. The Parco delle Mura represents an area of ??great value in the city, both from the point of view of urban and historical greenery, an investment that will allow the city to increase its tourist appeal even more, with a splendid path in the green and a dip in history for its citizens “.

The inauguration of the Parco delle Mura is part of the larger historical project “Spezia Forte” which also includes the Parco della Rimembranza, a Museum dedicated to the Cold War, the restoration of the former convent of the Poor Clares, the recovery of the Quintino Sella anti-aircraft gallery each identified with a specific brand, historical explanatory panels in Italian and English complete with information and QR code. The Parco delle Mura will become a new place for La Spezia people and tourists where, immersed in nature, they can take a dip in the past of our city, admire the breathtaking panorama with unprecedented views and also spend an unforgettable evening with the illuminated walls.

The project of “Redevelopment and recovery of the nineteenth-century walls of La Spezia”, ??has included and involved all those works necessary for the recovery and enhancement of the nineteenth-century walls of La Spezia to make the parallel path accessible to them which, together with the existing historical artifact relating to the so-called security belt, is organically inserted in a compendium that runs for about 4 km and is called “Parco delle mura”. This park is spread over the hilly area of ??La Spezia, embracing the historic nucleus of nineteenth-century expansion and develops in an almost continuous arc in an east-west direction starting from the area behind the Cathedral to the Collina di Gaggiola to the west, including exclusively the areas relating to the paths located outside and above the walls.

Finally, a video surveillance system was created to ensure maximum safety and also discourage phenomena of waste abandonment and a lighting system that will guarantee on the one hand the use of the site even in the evening and on the other will allow a very suggestive view of the walls in evening time from the city.

We would love to give thanks to the writer of this short article for this incredible web content

La Spezia, with the Parco delle Mura, the redevelopment of a historical and architectural path starts

[date_timestamp] => 1635258439 ) [2] => Array ( [title] => ÖFB Cup: WAC continues to struggle at the peat festival [link] => https://bofads.com/ofb-cup-wac-continues-to-struggle-at-the-peat-festival/ [dc] => Array ( [creator] => Pauline Moonlky ) [pubdate] => Tue, 26 Oct 2021 14:09:02 +0000 [category] => SportcontinuesCupFestivalÖFBpeatstruggleWAC [guid] => https://bofads.com/?p=3758 [description] => ÖFB-Cup The start of the round of 16 in the Uniqa-ÖFB-Cup brought a peat festival on Tuesday. The Bundesliga third WAC had to work overtime at the second division Lafnitz, but in the end won 5: 3 (2: 2) after extra time. The decisive goal was scored by Dominik Baumgartner of all people, who had ... Read more [content] => Array ( [encoded] =>

ÖFB-Cup

The start of the round of 16 in the Uniqa-ÖFB-Cup brought a peat festival on Tuesday. The Bundesliga third WAC had to work overtime at the second division Lafnitz, but in the end won 5: 3 (2: 2) after extra time. The decisive goal was scored by Dominik Baumgartner of all people, who had previously also scored in his own goal. The Carinthians turned a deficit twice with well-performing Styrians.

Matthäus Taferner brought the guests into the lead (19th), but Lafnitz turned the game around with Philipp Wendler (23rd) and a header by Baumgartner (26th). Before the break, a goalkeeper mistake led to 2-2 by Dario Vizinger (38th). The goalscorer took the place of goalgetter Tal Baribo after the Israeli was out with a muscle injury in his thigh. According to WAC coach Robin Dutt, Baribo will miss one or two more games.

In the second half, Lafnitz took the lead again through Thomas Schriebl (68th), but Christopher Wernitznig headed Wolfsberger into extra time (78th). In this, Lafnitz goalie Lucas Wabnig defused a shot by Michael Liendl (112th), seconds later Baumgartner put the corner kicked by the WAC director in the goal. Wernitznig (123rd) overcame Wabnig from a distance.

Goal to 3: 5 by Wernitznig (123.Min)

At the end of the day, Wernitznig tied up a double pack with a remarkable long-range shot.

?All’s well that ends well? for WAC

?I was badly positioned at the own goal, but I also know that I’m strong in such a situation,? said WAC defender Baumgartner after the game on ORF. His trainer Dutt spoke of a classic cupfight. ?We didn’t play a good game, our opponents did, so the class difference was evenly balanced. But we have always worked our way back, so the rule is: that ends well, everything is well, ?said the German after the game.

Baumgartner with own goal (26th min)

The WAC defender heads into his own case.

Lafnitz satisfied with performance

The fourth in the 2nd division was satisfied with the performance. ?We can be proud of our performance, even if it wasn’t enough in the end. We kept up well, but everything has to fit against a Bundesliga club, ?said Lafnitz striker Wendler. Coach Philipp Semlic took the same line: ?Our goal was to demand everything from our opponents with our game idea. In the end, we succeeded very well, even if the team was not rewarded for the effort. “

Schriebl scores to 3: 2 (68th Min)

A nice attack brings the new lead for Lafnitz.

On Tuesday (2.30 p.m.), the second Carinthian Bundesliga club Austria Klagenfurt will play at the regional division Weiz. The other six round of 16 games will take place on Wednesday and Thursday.

We would love to say thanks to the author of this short article for this incredible material

ÖFB Cup: WAC continues to struggle at the peat festival

) [summary] => ÖFB-Cup The start of the round of 16 in the Uniqa-ÖFB-Cup brought a peat festival on Tuesday. The Bundesliga third WAC had to work overtime at the second division Lafnitz, but in the end won 5: 3 (2: 2) after extra time. The decisive goal was scored by Dominik Baumgartner of all people, who had ... Read more [atom_content] =>

ÖFB-Cup

The start of the round of 16 in the Uniqa-ÖFB-Cup brought a peat festival on Tuesday. The Bundesliga third WAC had to work overtime at the second division Lafnitz, but in the end won 5: 3 (2: 2) after extra time. The decisive goal was scored by Dominik Baumgartner of all people, who had previously also scored in his own goal. The Carinthians turned a deficit twice with well-performing Styrians.

Matthäus Taferner brought the guests into the lead (19th), but Lafnitz turned the game around with Philipp Wendler (23rd) and a header by Baumgartner (26th). Before the break, a goalkeeper mistake led to 2-2 by Dario Vizinger (38th). The goalscorer took the place of goalgetter Tal Baribo after the Israeli was out with a muscle injury in his thigh. According to WAC coach Robin Dutt, Baribo will miss one or two more games.

In the second half, Lafnitz took the lead again through Thomas Schriebl (68th), but Christopher Wernitznig headed Wolfsberger into extra time (78th). In this, Lafnitz goalie Lucas Wabnig defused a shot by Michael Liendl (112th), seconds later Baumgartner put the corner kicked by the WAC director in the goal. Wernitznig (123rd) overcame Wabnig from a distance.

Goal to 3: 5 by Wernitznig (123.Min)

At the end of the day, Wernitznig tied up a double pack with a remarkable long-range shot.

?All’s well that ends well? for WAC

?I was badly positioned at the own goal, but I also know that I’m strong in such a situation,? said WAC defender Baumgartner after the game on ORF. His trainer Dutt spoke of a classic cupfight. ?We didn’t play a good game, our opponents did, so the class difference was evenly balanced. But we have always worked our way back, so the rule is: that ends well, everything is well, ?said the German after the game.

Baumgartner with own goal (26th min)

The WAC defender heads into his own case.

Lafnitz satisfied with performance

The fourth in the 2nd division was satisfied with the performance. ?We can be proud of our performance, even if it wasn’t enough in the end. We kept up well, but everything has to fit against a Bundesliga club, ?said Lafnitz striker Wendler. Coach Philipp Semlic took the same line: ?Our goal was to demand everything from our opponents with our game idea. In the end, we succeeded very well, even if the team was not rewarded for the effort. “

Schriebl scores to 3: 2 (68th Min)

A nice attack brings the new lead for Lafnitz.

On Tuesday (2.30 p.m.), the second Carinthian Bundesliga club Austria Klagenfurt will play at the regional division Weiz. The other six round of 16 games will take place on Wednesday and Thursday.

We would love to say thanks to the author of this short article for this incredible material

ÖFB Cup: WAC continues to struggle at the peat festival

[date_timestamp] => 1635257342 ) [3] => Array ( [title] => By playing appeasement, Erdogan and the West are avoiding the crisis [link] => https://bofads.com/by-playing-appeasement-erdogan-and-the-west-are-avoiding-the-crisis/ [dc] => Array ( [creator] => Tom Pauler ) [pubdate] => Tue, 26 Oct 2021 13:50:53 +0000 [category] => NewsappeasementavoidingcrisisErdoganplayingWest [guid] => https://bofads.com/?p=3752 [description] => Turkish President Recep Tayyip Erdogan addresses the press on October 25, 2021, in Ankara. MURAT CETINMUHURDAR / PPO / VIA REUTERS After causing a stir among the Western chancelleries, Turkish President Recep Tayyip Erdogan finally gave up his intention to expel ambassadors from ten countries – France, Germany, United States, Canada, Finland, Denmark, Netherlands, Norway, ... Read more [content] => Array ( [encoded] =>

After causing a stir among the Western chancelleries, Turkish President Recep Tayyip Erdogan finally gave up his intention to expel ambassadors from ten countries – France, Germany, United States, Canada, Finland, Denmark, Netherlands, Norway, Sweden, New Zealand – accused of interfering in Turkish internal affairs. Monday, October 25, when the Turkish government was going to meet to decide on the sanctions to be imposed, the embassies concerned defused the crisis, thus offering “A way out” to Erdogan, one explains among diplomats.

In a text published on its Twitter account, the United States Embassy recalled its attachment to the Vienna Convention, which governs diplomatic relations, and in particular to article 41, which prohibits any interference in the affairs of the host country. . Other concerned embassies relayed the same message. “Positively welcomed” by the Turkish number one, according to the official Anadolu news agency, the declaration was brandished as a victory by the whole pro-government media, elated by the “Recoil” foreign diplomacy. “After spitting, the ambassadors had to lick their sputum”, headline Monday the daily Yeni Akit. “I think they will be more careful in their statements”, President Erdogan concluded after the cabinet meeting.

In question, the public appeal that the ten ambassadors had launched on October 18 in favor of the release of the patron Osman Kavala, imprisoned for four years without trial despite a decision of the European Court of Human Rights (ECHR) ordering his release.

Read also In Turkey, Recep Tayyip Erdogan gives up expelling ten Western ambassadors

Outraged, Mr. Erdogan had declared loud and clear, twice last week, that he had ordered the expulsion of the signatories. The president’s remarks led to a fall in the Turkish lira, which fell to its all-time low (9.85 pounds to the dollar) when markets opened on Monday morning. The currency regained color on Tuesday (9.60 pounds to the dollar), driven by the announcement of the de-escalation.

Despite reiterated orders from the Turkish president, no official notification had been received by the chancelleries concerned. The Turkish Foreign Ministry has obviously been slow to implement the decision. According to some Turkish media, diplomats and advisers have made every effort to bring the president to his senses.

Discreet warnings

Sacking the ambassadors had serious consequences. The presence of the “world leader”, the nickname of Mr. Erdogan, at two major international meetings scheduled for the weekend, the G20 summit in Rome, Saturday, and the climate conference, the COP26, which takes place at the end of the week. opens Sunday in Glasgow, would have been compromised.

You have 59.82% of this article left to read. The rest is for subscribers only.

We wish to thank the author of this write-up for this awesome content

By playing appeasement, Erdogan and the West are avoiding the crisis

) [summary] => Turkish President Recep Tayyip Erdogan addresses the press on October 25, 2021, in Ankara. MURAT CETINMUHURDAR / PPO / VIA REUTERS After causing a stir among the Western chancelleries, Turkish President Recep Tayyip Erdogan finally gave up his intention to expel ambassadors from ten countries – France, Germany, United States, Canada, Finland, Denmark, Netherlands, Norway, ... Read more [atom_content] =>

After causing a stir among the Western chancelleries, Turkish President Recep Tayyip Erdogan finally gave up his intention to expel ambassadors from ten countries – France, Germany, United States, Canada, Finland, Denmark, Netherlands, Norway, Sweden, New Zealand – accused of interfering in Turkish internal affairs. Monday, October 25, when the Turkish government was going to meet to decide on the sanctions to be imposed, the embassies concerned defused the crisis, thus offering “A way out” to Erdogan, one explains among diplomats.

In a text published on its Twitter account, the United States Embassy recalled its attachment to the Vienna Convention, which governs diplomatic relations, and in particular to article 41, which prohibits any interference in the affairs of the host country. . Other concerned embassies relayed the same message. “Positively welcomed” by the Turkish number one, according to the official Anadolu news agency, the declaration was brandished as a victory by the whole pro-government media, elated by the “Recoil” foreign diplomacy. “After spitting, the ambassadors had to lick their sputum”, headline Monday the daily Yeni Akit. “I think they will be more careful in their statements”, President Erdogan concluded after the cabinet meeting.

In question, the public appeal that the ten ambassadors had launched on October 18 in favor of the release of the patron Osman Kavala, imprisoned for four years without trial despite a decision of the European Court of Human Rights (ECHR) ordering his release.

Read also In Turkey, Recep Tayyip Erdogan gives up expelling ten Western ambassadors

Outraged, Mr. Erdogan had declared loud and clear, twice last week, that he had ordered the expulsion of the signatories. The president’s remarks led to a fall in the Turkish lira, which fell to its all-time low (9.85 pounds to the dollar) when markets opened on Monday morning. The currency regained color on Tuesday (9.60 pounds to the dollar), driven by the announcement of the de-escalation.

Despite reiterated orders from the Turkish president, no official notification had been received by the chancelleries concerned. The Turkish Foreign Ministry has obviously been slow to implement the decision. According to some Turkish media, diplomats and advisers have made every effort to bring the president to his senses.

Discreet warnings

Sacking the ambassadors had serious consequences. The presence of the “world leader”, the nickname of Mr. Erdogan, at two major international meetings scheduled for the weekend, the G20 summit in Rome, Saturday, and the climate conference, the COP26, which takes place at the end of the week. opens Sunday in Glasgow, would have been compromised.

You have 59.82% of this article left to read. The rest is for subscribers only.

We wish to thank the author of this write-up for this awesome content

By playing appeasement, Erdogan and the West are avoiding the crisis

[date_timestamp] => 1635256253 ) [4] => Array ( [title] => Interview: Identifying talent at Nasa using data science [link] => https://bofads.com/interview-identifying-talent-at-nasa-using-data-science/ [dc] => Array ( [creator] => Harold Kent ) [pubdate] => Tue, 26 Oct 2021 13:39:15 +0000 [category] => SpacedataIdentifyinginterviewNASAsciencetalent [guid] => https://bofads.com/?p=3746 [description] => David Meza, acting branch chief of people analytics and senior data scientist at Nasa, is helping the US space agency to identify its key data science skills gaps and to put in place a series of programmes to help the organisation secure the expertise it needs. With analyst Gartner suggesting that more than half (53%) ... Read more [content] => Array ( [encoded] =>

David Meza, acting branch chief of people analytics and senior data scientist at Nasa, is helping the US space agency to identify its key data science skills gaps and to put in place a series of programmes to help the organisation secure the expertise it needs.

With analyst Gartner suggesting that more than half (53%) of companies believe the inability to identify in-demand skills is the biggest impediment to business transformation, Meza?s work at Nasa could help the agency find the next-generation capability it needs to fulfil some of its most important work during the next few decades ? including space travel and beyond.

?Of course, that?s definitely part of it ? when we?re in the news, you see a lot of the things we?re trying to do, like go back to the Moon or onto Mars,? he says. ?But we also have other areas that we work on. Earth science is a big area within Nasa, and climate change and climate control.

?We also have things that we?re working on within the area of supercomputing ? we do a lot of research in aeronautics. We support a lot of development activity within different types of software applications and we?re undertaking pioneering work in medical areas, too.?

As acting branch chief, Meza is filling in for the permanent head, who will return at the end of the year. His primary role is to lead the agency?s exploitation of artificial intelligence and machine learning architecture and infrastructure across people resources, with the aim of enhancing and developing human capital processes.

?It?s about using these kinds of advanced data tools to identify various issues, metrics and analysis,? he says. ?We?re looking around our workforce and trying to get a better handle on our workforce: do we have the right skills, do we have the right people in the right place, are we losing people, and what kind of skills are we losing??

?I?m trying to discover and uncover answers from our data, to improve our use of our data and to help drive data-driven decisions?

David Meza, Nasa

That?s a big project for Meza and it requires him to draw on his vast experience, which includes 20 years at Nasa. He?s spent most of that time with the Johnson Space Center in Houston. For 10 of those years, he fulfilled the role of chief knowledge architect. Meza moved to Nasa headquarters in 2019 to take on his current role.

?I?m basically doing the same thing as I was as a chief knowledge architect, but it?s about specialising in the human capital domain,? he says. ?I?m really just trying to enhance our capabilities and use the newer technologies that are available today.? Meza adds that the opportunity to find new answers to challenging questions is his key motivation.

?I?ve always been a technical guy,? he says. ?I?m trying to discover and uncover answers from our data, to improve our use of our data and to help drive data-driven decisions. That?s about helping us to really understand and utilise data for good more than anything else. Data can be used for many different things, but to really use it to help understanding our workforce is key ? and I really like playing with the data.?

Analysing workflows and identifying openings

Meza says one of the primary projects he is leading in the area of human capital is the roll-out and implementation of what Nasa calls the enterprise data platform, which is a group of tools and an associated framework that aims to modernise the organisation?s analytical workflow. He says this work stretches from everything to the agency?s data sources all the way to the presentation layer it uses.

?That work involves updating and upgrading our data warehouse and our data lake-type capabilities, enhancing our analytical workflow, and utilising cloud technologies, as well as other mechanisms,? says Meza.

?It?s all about looking at how we catalogue our data, how we track it, how we create metadata and data dictionaries, and then on to the visualisation aspect ? and there are various ways of doing that, too.?

As part of that work, Meza is looking at how the human capital team enhances its analytical workflows and data models. That exploration exercise involves investigating how the organisation might use machine-learning technology to ensure it keeps track of its data models, and how these models might be refined operationally.

Another major element of Meza?s work is around the continuing support and development of Nasa?s talent marketplace, which is the agency?s internal job-listing and candidate-selection platform. This marketplace gives employees access to a range of internal career development opportunities at their local centres and across the wider organisation.

This platform forms part of the agency?s Future of Work initiative, which is an investigation of the roles and skills that might be required during the next 60 years at home and in space. Meza says his team continues to refine how data is used in the marketplace as part of this long-term initiative.

?We?re doing a lot of different assessments,? he says. ?We?re looking at evaluating and validating some of the models that we?ve already developed to try to see if we correctly identified the right types of knowledge and skills that are within the workforce.

?We?re doing some training needs assessments and literacy assessments. Late last year, we started a digital transformation effort, which is still going go on through this year. That work remains in development and we?re still trying to work through some of those things.?

Implementing graph technology to show relationships

What is already clear, says Meza, is that data talent is spread across Nasa, some of which is not easily identified or categorised due to the wide range of work taking place at the space agency. Help comes in the form of another of Meza?s key initiatives ? a talent-mapping database to identify the data skills required for all kinds of projects.

The talent-mapping database is still being developed, but it uses Neo4j technology to build a knowledge graph. Meza first started using Neo4j?s knowledge graph more than a decade ago. In the case of human capital at the space agency, the graph is designed to show the complex and varied relationships between people, skills and projects.

As a starting point, Meza?s team focused on creating an occupational taxonomy, which analysed the key components of a role from an employee, training and project perspective. To help build this taxonomy, they made use of a database from the US Department of Labor called O*NET, which has descriptions and skillsets for hundreds of occupations.

Capturing those components allowed his team to build a model of the skills associated to different roles at Nasa ? and to start identifying people with skills who could fill those occupations. The model also highlights the kinds of ability that other individuals in Nasa might need to complete tasks in each occupation successfully.

Meza and his team will then get employees across the agency to validate the skills and tasks associated to each occupation, and they will use this feedback to train the model. They will then develop an end-user application and create an interface. Hopefully, by the end of this year, people in Nasa will be using the system to search for talent and potential job opportunities.

Managers will be able to use the talent-mapping database to track skills gaps and boost training in hard-to-fill areas, while employees will be able to use the technology to discover how to upskill if they want to move into new areas of work.

?Within our talent marketplace, we offer opportunities to employees across Nasa to do different types of work,? says Meza. ?Having a work role that is connected to the system will allow us to hopefully find individuals that closely match what we?re looking for. Conversely, an employee who really wants to start doing a particular role can find out what kind of opportunities are out there and think about how to reach that destination.?

Helping to shape next-generational capability

Meza says that implementing all these data-led technologies is just one element of the puzzle. To really help Nasa find and train the next-generation talent it needs, managers and employees will have to get used to making the most of the technology that his team is implementing. Meza recognises that process requires a shift in mindset.

?It involves a lot of communication, and sometimes a lot of grovelling and begging,? he says. ?I say that tongue-in-cheek, but it?s hard to move an organisation ? not just Nasa, but any organisation ? that has an embedded system and to try and get them to do something different. A lot of the time, that means working in parallel to begin with, which means added costs before you can completely switch over.?

However, Meza believes this joined-up approach will help everyone in the organisation to begin to see how data and technology can be applied in combination to help Nasa overcome some of its most intractable skills challenges. As the technology proves its worth, he expects the agency to begin to think about how graph systems might be applied in other areas.

For now, Meza is keen to continue developing innovative ways to help Nasa fill its most significant skills gaps. When he thinks about the continuing requirement for talent in the agency, he believes the data scientist of the future will be part of a cohesive and collaborative group ? and the technology that his team is developing right now will help point skilled individuals in the right direction.

?As we start to develop our infrastructure and our capabilities to have model libraries and to share code more easily, I think you?ll see data scientists that can easily pick up different domains based on these models and identify how they might be able to use these tools within their own domains,? he says. ?So I think shareability and the use of models is definitely something that?s going to increase.?

We would like to thank the author of this post for this awesome content

Interview: Identifying talent at Nasa using data science

) [summary] => David Meza, acting branch chief of people analytics and senior data scientist at Nasa, is helping the US space agency to identify its key data science skills gaps and to put in place a series of programmes to help the organisation secure the expertise it needs. With analyst Gartner suggesting that more than half (53%) ... Read more [atom_content] =>

David Meza, acting branch chief of people analytics and senior data scientist at Nasa, is helping the US space agency to identify its key data science skills gaps and to put in place a series of programmes to help the organisation secure the expertise it needs.

With analyst Gartner suggesting that more than half (53%) of companies believe the inability to identify in-demand skills is the biggest impediment to business transformation, Meza?s work at Nasa could help the agency find the next-generation capability it needs to fulfil some of its most important work during the next few decades ? including space travel and beyond.

?Of course, that?s definitely part of it ? when we?re in the news, you see a lot of the things we?re trying to do, like go back to the Moon or onto Mars,? he says. ?But we also have other areas that we work on. Earth science is a big area within Nasa, and climate change and climate control.

?We also have things that we?re working on within the area of supercomputing ? we do a lot of research in aeronautics. We support a lot of development activity within different types of software applications and we?re undertaking pioneering work in medical areas, too.?

As acting branch chief, Meza is filling in for the permanent head, who will return at the end of the year. His primary role is to lead the agency?s exploitation of artificial intelligence and machine learning architecture and infrastructure across people resources, with the aim of enhancing and developing human capital processes.

?It?s about using these kinds of advanced data tools to identify various issues, metrics and analysis,? he says. ?We?re looking around our workforce and trying to get a better handle on our workforce: do we have the right skills, do we have the right people in the right place, are we losing people, and what kind of skills are we losing??

?I?m trying to discover and uncover answers from our data, to improve our use of our data and to help drive data-driven decisions?

David Meza, Nasa

That?s a big project for Meza and it requires him to draw on his vast experience, which includes 20 years at Nasa. He?s spent most of that time with the Johnson Space Center in Houston. For 10 of those years, he fulfilled the role of chief knowledge architect. Meza moved to Nasa headquarters in 2019 to take on his current role.

?I?m basically doing the same thing as I was as a chief knowledge architect, but it?s about specialising in the human capital domain,? he says. ?I?m really just trying to enhance our capabilities and use the newer technologies that are available today.? Meza adds that the opportunity to find new answers to challenging questions is his key motivation.

?I?ve always been a technical guy,? he says. ?I?m trying to discover and uncover answers from our data, to improve our use of our data and to help drive data-driven decisions. That?s about helping us to really understand and utilise data for good more than anything else. Data can be used for many different things, but to really use it to help understanding our workforce is key ? and I really like playing with the data.?

Analysing workflows and identifying openings

Meza says one of the primary projects he is leading in the area of human capital is the roll-out and implementation of what Nasa calls the enterprise data platform, which is a group of tools and an associated framework that aims to modernise the organisation?s analytical workflow. He says this work stretches from everything to the agency?s data sources all the way to the presentation layer it uses.

?That work involves updating and upgrading our data warehouse and our data lake-type capabilities, enhancing our analytical workflow, and utilising cloud technologies, as well as other mechanisms,? says Meza.

?It?s all about looking at how we catalogue our data, how we track it, how we create metadata and data dictionaries, and then on to the visualisation aspect ? and there are various ways of doing that, too.?

As part of that work, Meza is looking at how the human capital team enhances its analytical workflows and data models. That exploration exercise involves investigating how the organisation might use machine-learning technology to ensure it keeps track of its data models, and how these models might be refined operationally.

Another major element of Meza?s work is around the continuing support and development of Nasa?s talent marketplace, which is the agency?s internal job-listing and candidate-selection platform. This marketplace gives employees access to a range of internal career development opportunities at their local centres and across the wider organisation.

This platform forms part of the agency?s Future of Work initiative, which is an investigation of the roles and skills that might be required during the next 60 years at home and in space. Meza says his team continues to refine how data is used in the marketplace as part of this long-term initiative.

?We?re doing a lot of different assessments,? he says. ?We?re looking at evaluating and validating some of the models that we?ve already developed to try to see if we correctly identified the right types of knowledge and skills that are within the workforce.

?We?re doing some training needs assessments and literacy assessments. Late last year, we started a digital transformation effort, which is still going go on through this year. That work remains in development and we?re still trying to work through some of those things.?

Implementing graph technology to show relationships

What is already clear, says Meza, is that data talent is spread across Nasa, some of which is not easily identified or categorised due to the wide range of work taking place at the space agency. Help comes in the form of another of Meza?s key initiatives ? a talent-mapping database to identify the data skills required for all kinds of projects.

The talent-mapping database is still being developed, but it uses Neo4j technology to build a knowledge graph. Meza first started using Neo4j?s knowledge graph more than a decade ago. In the case of human capital at the space agency, the graph is designed to show the complex and varied relationships between people, skills and projects.

As a starting point, Meza?s team focused on creating an occupational taxonomy, which analysed the key components of a role from an employee, training and project perspective. To help build this taxonomy, they made use of a database from the US Department of Labor called O*NET, which has descriptions and skillsets for hundreds of occupations.

Capturing those components allowed his team to build a model of the skills associated to different roles at Nasa ? and to start identifying people with skills who could fill those occupations. The model also highlights the kinds of ability that other individuals in Nasa might need to complete tasks in each occupation successfully.

Meza and his team will then get employees across the agency to validate the skills and tasks associated to each occupation, and they will use this feedback to train the model. They will then develop an end-user application and create an interface. Hopefully, by the end of this year, people in Nasa will be using the system to search for talent and potential job opportunities.

Managers will be able to use the talent-mapping database to track skills gaps and boost training in hard-to-fill areas, while employees will be able to use the technology to discover how to upskill if they want to move into new areas of work.

?Within our talent marketplace, we offer opportunities to employees across Nasa to do different types of work,? says Meza. ?Having a work role that is connected to the system will allow us to hopefully find individuals that closely match what we?re looking for. Conversely, an employee who really wants to start doing a particular role can find out what kind of opportunities are out there and think about how to reach that destination.?

Helping to shape next-generational capability

Meza says that implementing all these data-led technologies is just one element of the puzzle. To really help Nasa find and train the next-generation talent it needs, managers and employees will have to get used to making the most of the technology that his team is implementing. Meza recognises that process requires a shift in mindset.

?It involves a lot of communication, and sometimes a lot of grovelling and begging,? he says. ?I say that tongue-in-cheek, but it?s hard to move an organisation ? not just Nasa, but any organisation ? that has an embedded system and to try and get them to do something different. A lot of the time, that means working in parallel to begin with, which means added costs before you can completely switch over.?

However, Meza believes this joined-up approach will help everyone in the organisation to begin to see how data and technology can be applied in combination to help Nasa overcome some of its most intractable skills challenges. As the technology proves its worth, he expects the agency to begin to think about how graph systems might be applied in other areas.

For now, Meza is keen to continue developing innovative ways to help Nasa fill its most significant skills gaps. When he thinks about the continuing requirement for talent in the agency, he believes the data scientist of the future will be part of a cohesive and collaborative group ? and the technology that his team is developing right now will help point skilled individuals in the right direction.

?As we start to develop our infrastructure and our capabilities to have model libraries and to share code more easily, I think you?ll see data scientists that can easily pick up different domains based on these models and identify how they might be able to use these tools within their own domains,? he says. ?So I think shareability and the use of models is definitely something that?s going to increase.?

We would like to thank the author of this post for this awesome content

Interview: Identifying talent at Nasa using data science

[date_timestamp] => 1635255555 ) [5] => Array ( [title] => Scientists uncover a gene involved in sexual conflict in fruit flies [link] => https://bofads.com/scientists-uncover-a-gene-involved-in-sexual-conflict-in-fruit-flies/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Tue, 26 Oct 2021 13:38:18 +0000 [category] => Health And ScienceconflictfliesfruitgeneinvolvedScientistssexualuncover [guid] => https://bofads.com/?p=3741 [description] => Journal Reference: Mohanakarthik P. Nallasivan, Irmgard U. Haussmann, Alberto Civetta, Matthias Soller. Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring of female reproductive behaviors in Drosophila. BMC Biology, 2021; 19 (1) DOI: 10.1186/s12915-021-01154-6 The research uncovers a gene directing development of these neurons and sheds new light on how certain behaviours ? ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Mohanakarthik P. Nallasivan, Irmgard U. Haussmann, Alberto Civetta, Matthias Soller. Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring of female reproductive behaviors in Drosophila. BMC Biology, 2021; 19 (1) DOI: 10.1186/s12915-021-01154-6

The research uncovers a gene directing development of these neurons and sheds new light on how certain behaviours ? in this case sexual behaviours ? are ?hardwired? into the brain. It also shows how sexual conflict drives the evolution of new species and offers a step towards understanding the process of evolution at a molecular and cellular level.

Dr Matthias Soller, the lead author on the paper, explained: ?Darwin?s theory on the origins of species is fundamental to evolutionary biology. But the molecular and cellular drivers of evolution are still a mystery.? Co-author Dr Irmgard Haussmann from Birmingham City University adds ?Even we humans are evolving: 100 years ago no one thought of our electronic world requiring to adapt our brain to completely new tasks.?

While this research offers a way to answer fundamental science questions, understanding the genetics of sexual behaviour could also lead, eventually, to new ways of controlling insect populations, for example in crop management or spread of insect-borne diseases like Malaria.

In the study, published in a BMC Biology collection ?Neurons, Circuits and Behavior?, the researchers focused on a particular molecule ? called sex peptide ? which is passed from the male fruit fly to the female during mating. Sex peptide is responsible for triggering the female?s post-mating behaviour, for example rejecting courting males and increasing the urge to lay eggs.

But sometimes the female needs to resist these behaviours, for example if there is not enough food, or if there are environmental reasons to not lay eggs. The ability to do this relies on a genetic mutation that the researchers were able to identify. This mutation affected the female?s response to sex peptide and, having identified the mutation, the researchers were able to identify the specific gene that is essential for regulating the female?s post-mating response.

Significantly, they found the gene, called Nup54, was present in every cell. Rather than being a signalling molecule present in a few neurons, as the research team expected, the Nup54 protein is a component of every cell?s nuclear pore ? the part of the cell that regulates which proteins are allowed into the nucleus and which messenger RNAs pass out of the nucleus for translation into protein.

?Nuclear pore genes are among the few genes that have been associated with the occurrence of new species,? says Dr Soller. ?We think it?s likely that these changes, including wiring of the brain and a change in behaviour, mark a very early stage of speciation, and therefore show one of the first cellular processes in evolution of new species.?

We would like to thank the author of this short article for this awesome material

Scientists uncover a gene involved in sexual conflict in fruit flies

) [summary] => Journal Reference: Mohanakarthik P. Nallasivan, Irmgard U. Haussmann, Alberto Civetta, Matthias Soller. Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring of female reproductive behaviors in Drosophila. BMC Biology, 2021; 19 (1) DOI: 10.1186/s12915-021-01154-6 The research uncovers a gene directing development of these neurons and sheds new light on how certain behaviours ? ... Read more [atom_content] =>

Journal Reference:

  1. Mohanakarthik P. Nallasivan, Irmgard U. Haussmann, Alberto Civetta, Matthias Soller. Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring of female reproductive behaviors in Drosophila. BMC Biology, 2021; 19 (1) DOI: 10.1186/s12915-021-01154-6

The research uncovers a gene directing development of these neurons and sheds new light on how certain behaviours ? in this case sexual behaviours ? are ?hardwired? into the brain. It also shows how sexual conflict drives the evolution of new species and offers a step towards understanding the process of evolution at a molecular and cellular level.

Dr Matthias Soller, the lead author on the paper, explained: ?Darwin?s theory on the origins of species is fundamental to evolutionary biology. But the molecular and cellular drivers of evolution are still a mystery.? Co-author Dr Irmgard Haussmann from Birmingham City University adds ?Even we humans are evolving: 100 years ago no one thought of our electronic world requiring to adapt our brain to completely new tasks.?

While this research offers a way to answer fundamental science questions, understanding the genetics of sexual behaviour could also lead, eventually, to new ways of controlling insect populations, for example in crop management or spread of insect-borne diseases like Malaria.

In the study, published in a BMC Biology collection ?Neurons, Circuits and Behavior?, the researchers focused on a particular molecule ? called sex peptide ? which is passed from the male fruit fly to the female during mating. Sex peptide is responsible for triggering the female?s post-mating behaviour, for example rejecting courting males and increasing the urge to lay eggs.

But sometimes the female needs to resist these behaviours, for example if there is not enough food, or if there are environmental reasons to not lay eggs. The ability to do this relies on a genetic mutation that the researchers were able to identify. This mutation affected the female?s response to sex peptide and, having identified the mutation, the researchers were able to identify the specific gene that is essential for regulating the female?s post-mating response.

Significantly, they found the gene, called Nup54, was present in every cell. Rather than being a signalling molecule present in a few neurons, as the research team expected, the Nup54 protein is a component of every cell?s nuclear pore ? the part of the cell that regulates which proteins are allowed into the nucleus and which messenger RNAs pass out of the nucleus for translation into protein.

?Nuclear pore genes are among the few genes that have been associated with the occurrence of new species,? says Dr Soller. ?We think it?s likely that these changes, including wiring of the brain and a change in behaviour, mark a very early stage of speciation, and therefore show one of the first cellular processes in evolution of new species.?

We would like to thank the author of this short article for this awesome material

Scientists uncover a gene involved in sexual conflict in fruit flies

[date_timestamp] => 1635255498 ) [6] => Array ( [title] => Anti-Covid-19 pill: France has ordered 50,000 doses manufactured by the American Merck [link] => https://bofads.com/anti-covid-19-pill-france-has-ordered-50000-doses-manufactured-by-the-american-merck/ [dc] => Array ( [creator] => Sally Scully ) [pubdate] => Tue, 26 Oct 2021 13:35:59 +0000 [category] => PlanetAmericanAntiCovid19dosesFrancemanufacturedMerckpill [guid] => https://bofads.com/?p=3735 [description] => Antiviral from Merck, October 1, 2021. AP He could be a game-changer in the fight against the epidemic. While the European health authorities are examining this antiviral treatment which could be crucial in the fight against the epidemic, the Minister of Health, Olivier Véran, announced, Tuesday October 26, during a hearing in the Senate, that ... Read more [content] => Array ( [encoded] =>

He could be a game-changer in the fight against the epidemic. While the European health authorities are examining this antiviral treatment which could be crucial in the fight against the epidemic, the Minister of Health, Olivier Véran, announced, Tuesday October 26, during a hearing in the Senate, that France has ordered 50,000 doses of the anti-Covid-19 pill from the American laboratory Merck. At the same hearing, Mr. Véran also said that two-thirds of caregivers were now vaccinated.

France has again reached 5,000 daily SARS-Co-2 contaminations: figures from Public Health France published on Monday show that contaminations have been on the rise again since October 20. If we smooth the numbers over a week, Monday was the third day in a row that the number of new daily cases stood above 5,000. There were 5,084 on Saturday, 5,259 on Sunday and 5,293 on Monday. , while this indicator did not exceed 4,700 cases until October 19.

The government and epidemiologists have insisted in recent weeks on the need to maintain barrier gestures to contain the pandemic, despite the benefits of vaccination.

  • 50,000 doses of Merck’s Covid-19 treatment ordered

“Fifty thousand doses of this drug will be delivered to France from the last days of November or the first days of December, that is to say as soon as the treatments leave the production lines”, Olivier Véran said on Tuesday.

Merck, called MSD outside of North America to distinguish it from a German namesake, reported in early October very encouraging results for this antiviral. According to the American laboratory, which has carried out tests on nearly 800 patients but has yet to make the details public, molnupiravir halves the risk of hospitalization when it is given to patients who have just been tested positive for Covid -19. The group has requested authorization for the treatment from both American and European health authorities, the latter having announced on Monday that they were starting an accelerated procedure.

According to Mr. Véran, the major advantage of this drug is that it is taken in oral form and could therefore be used much easier than intravenous treatments such as, for example, those based on synthetic antibodies. “Imagine that we had [au début de la crise sanitaire] antiviral treatment which reduced the number of serious cases by 50%, imagine the health impact in our country at the heart of the first and second waves, we would have had far fewer deaths and far fewer serious cases “, welcomed the Minister. However, he recalled that this treatment cannot be the only response to the epidemic, stressing the importance of vaccination against Covid-19.

“Vaccination plus antiviral treatment plus monoclonal antibodies equals much lower health impact”, he insisted. This set “We would also put (?) safe in the event of an epidemic wave linked to a new variant of which the damage it could cause is still unknown ?, he concluded. The cost of treatment will be high a priori. Mr. Véran did not specify the amount of the order but, by way of example, the United States ordered 1.7 million doses for $ 1.2 billion this year, or about $ 700 (602 euros ) for each.

Read also Merck’s anti-Covid-19 pill: European Medicines Agency launches expedited review
  • Two-thirds of suspended caregivers now vaccinated

?From the first lifts I have, two-thirds of suspended caregivers returned to work once vaccinated. It’s good “, declared Olivier Véran during a hearing in the Senate on the bill on health vigilance.

“We are therefore at a vaccination coverage rate for employees of health and medico-social establishments which is extremely high, and a rate of suspensions and resignations which is extremely low”, he continued, without saying how many suspensions are in progress. The Minister Delegate for Autonomy, Brigitte Bourguignon, had clarified in the National Assembly on October 20 that on that date 7,930 caregivers were suspended in France.

Read also Vaccination obligation: more than 1,400 employees of unvaccinated health establishments suspended in Ile-de-France

Already obliged since September 15 to justify at least one injection, employees of hospitals, clinics and retirement homes, as well as liberal caregivers, home helpers, firefighters and ambulance attendants, i.e. 2.7 million workers, have since on November 15, attest to a “Complete diagram” vaccination, under penalty of suspension of their employment contract, without remuneration.

Read also Article reserved for our subscribers “Here, we prefer to close hospital beds and fire unvaccinated staff”

The World with AFP

We wish to give thanks to the author of this short article for this incredible material

Anti-Covid-19 pill: France has ordered 50,000 doses manufactured by the American Merck

) [summary] => Antiviral from Merck, October 1, 2021. AP He could be a game-changer in the fight against the epidemic. While the European health authorities are examining this antiviral treatment which could be crucial in the fight against the epidemic, the Minister of Health, Olivier Véran, announced, Tuesday October 26, during a hearing in the Senate, that ... Read more [atom_content] =>

He could be a game-changer in the fight against the epidemic. While the European health authorities are examining this antiviral treatment which could be crucial in the fight against the epidemic, the Minister of Health, Olivier Véran, announced, Tuesday October 26, during a hearing in the Senate, that France has ordered 50,000 doses of the anti-Covid-19 pill from the American laboratory Merck. At the same hearing, Mr. Véran also said that two-thirds of caregivers were now vaccinated.

France has again reached 5,000 daily SARS-Co-2 contaminations: figures from Public Health France published on Monday show that contaminations have been on the rise again since October 20. If we smooth the numbers over a week, Monday was the third day in a row that the number of new daily cases stood above 5,000. There were 5,084 on Saturday, 5,259 on Sunday and 5,293 on Monday. , while this indicator did not exceed 4,700 cases until October 19.

The government and epidemiologists have insisted in recent weeks on the need to maintain barrier gestures to contain the pandemic, despite the benefits of vaccination.

  • 50,000 doses of Merck’s Covid-19 treatment ordered

“Fifty thousand doses of this drug will be delivered to France from the last days of November or the first days of December, that is to say as soon as the treatments leave the production lines”, Olivier Véran said on Tuesday.

Merck, called MSD outside of North America to distinguish it from a German namesake, reported in early October very encouraging results for this antiviral. According to the American laboratory, which has carried out tests on nearly 800 patients but has yet to make the details public, molnupiravir halves the risk of hospitalization when it is given to patients who have just been tested positive for Covid -19. The group has requested authorization for the treatment from both American and European health authorities, the latter having announced on Monday that they were starting an accelerated procedure.

According to Mr. Véran, the major advantage of this drug is that it is taken in oral form and could therefore be used much easier than intravenous treatments such as, for example, those based on synthetic antibodies. “Imagine that we had [au début de la crise sanitaire] antiviral treatment which reduced the number of serious cases by 50%, imagine the health impact in our country at the heart of the first and second waves, we would have had far fewer deaths and far fewer serious cases “, welcomed the Minister. However, he recalled that this treatment cannot be the only response to the epidemic, stressing the importance of vaccination against Covid-19.

“Vaccination plus antiviral treatment plus monoclonal antibodies equals much lower health impact”, he insisted. This set “We would also put (?) safe in the event of an epidemic wave linked to a new variant of which the damage it could cause is still unknown ?, he concluded. The cost of treatment will be high a priori. Mr. Véran did not specify the amount of the order but, by way of example, the United States ordered 1.7 million doses for $ 1.2 billion this year, or about $ 700 (602 euros ) for each.

Read also Merck’s anti-Covid-19 pill: European Medicines Agency launches expedited review
  • Two-thirds of suspended caregivers now vaccinated

?From the first lifts I have, two-thirds of suspended caregivers returned to work once vaccinated. It’s good “, declared Olivier Véran during a hearing in the Senate on the bill on health vigilance.

“We are therefore at a vaccination coverage rate for employees of health and medico-social establishments which is extremely high, and a rate of suspensions and resignations which is extremely low”, he continued, without saying how many suspensions are in progress. The Minister Delegate for Autonomy, Brigitte Bourguignon, had clarified in the National Assembly on October 20 that on that date 7,930 caregivers were suspended in France.

Read also Vaccination obligation: more than 1,400 employees of unvaccinated health establishments suspended in Ile-de-France

Already obliged since September 15 to justify at least one injection, employees of hospitals, clinics and retirement homes, as well as liberal caregivers, home helpers, firefighters and ambulance attendants, i.e. 2.7 million workers, have since on November 15, attest to a “Complete diagram” vaccination, under penalty of suspension of their employment contract, without remuneration.

Read also Article reserved for our subscribers “Here, we prefer to close hospital beds and fire unvaccinated staff”

The World with AFP

We wish to give thanks to the author of this short article for this incredible material

Anti-Covid-19 pill: France has ordered 50,000 doses manufactured by the American Merck

[date_timestamp] => 1635255359 ) [7] => Array ( [title] => Sanremo 2022, the regulation. 24 champions in the competition and the ?Demoscopica 1.000? arrives among the juries [link] => https://bofads.com/sanremo-2022-the-regulation-24-champions-in-the-competition-and-the-demoscopica-1-000-arrives-among-the-juries/ [dc] => Array ( [creator] => Paula Hooper ) [pubdate] => Tue, 26 Oct 2021 13:24:06 +0000 [category] => MusicarriveschampionscompetitionDemoscopicajuriesregulationSanremo [guid] => https://bofads.com/?p=3731 [description] => Sanremo 2022 evenings. The official regulation of the Sanremo Festival. Let’s go immediately to find out what are the main news and how we will vote night by night. Confirmed the number of artists competing. They will be twenty four of which twenty-two chosen by the artistic director Amadeus and two promoted on the field ... Read more [content] => Array ( [encoded] =>

Sanremo 2022 evenings. The official regulation of the Sanremo Festival. Let’s go immediately to find out what are the main news and how we will vote night by night.

Confirmed the number of artists competing. They will be twenty four of which twenty-two chosen by the artistic director Amadeus and two promoted on the field the December 15, 2021 gives Sanremo young.

The voting system has been completely renewed with three independent juries with accredited journalists from the press, radio, TV and Web, the confirmation of televoting and the debut of the Demoscopic 1,000.

For all 24 – from Tuesday February 1 live on Rai1, RaiPlay e Radio2 – it will be a race without eliminations to get to the final evening of Saturday 5, with the announcement of the winner.

In addition, the special evening of the Cover di Friday 4th February, during which the artists will perform – alone or with a guest agreed with Rai and with the Artistic Direction – a piece that can be taken not only from the Italian repertoire, but also from the international repertoire of the 60 ‘, 70’ or 80 ‘.

who you can read the regulation Rai in its full version.

Sanremo 2022 evenings: The votes

In the first two evenings, the jury of accredited journalists will vote, divided into three independent voting components: a jury from print and TV, one from radio and one from the web.

In the fourth and fifth evening, however, the Jury of the Press Room, TV, Radio and Web will vote as a single component, joining the Televoting and the Jury 1000 opinion poll, composed of a thousand components selected according to balanced criteria of age and geographical origin, who will vote remotely with an app dedicated to them.

The conduct of the evenings

The conduct of the evenings provides that Tuesday 1 e Wednesday 2 February 12 songs in the competition are performed by the respective 12 Artists who will be voted, separately, by the 3 voting components of the Press, TV, Radio and Web Jury. The percentage weight on the overall result of the vote will be divided as follows: print media and TV 33 percent; 33 percent web jury; radio jury 34 percent.

After the vote, a ranking of the 12 songs / artists performed in each of the two evenings will be drawn up.

In the third evening the 24 artists will propose the 24 songs in the competition that will be voted on by the public through televoting and by the jury 1000 opinion poll which will have an impact on the overall result of 50 percent.

The average between the overall voting percentages obtained by the songs / artists in the evening and those obtained in the previous evenings will determine a new ranking of the 24 songs / artists in the competition.

In the ?Cover? evening by Friday 4th February each of the 24 artists competing, will propose – alone or with a guest – a song from the Italian and international repertoire of the 60 ‘, 70’ and 80 ‘that will be voted by all the juries with a percentage weight of 34% for Televoto ; 33% for the Jury of the Press Room, TV, Radio and Web; and 33% for the 1000 opinion poll.

The average between the overall percentages of votes obtained by the Artists in the evening and those obtained in the previous evenings will determine a new ranking of the 24 songs / Artists in the competition.

Finally, on the final evening, the 24 songs in the competition will be voted on by the public through televoting and the average between the percentages of votes obtained in the evening and those obtained in the previous evenings will determine a new ranking of the 24 songs / artists.

The first three songs in the chart will be repeated through live performance or through audio-video recording. Previous votes will be cleared and a new audience vote will be held with Televoto; of the Press, TV, Radio and Web Jury; and of the Demoscopica 1000, with a percentage weight divided as follows: Televoto 34%: Jury of the Press Room, TV, Radio and Web 33%; Demoscopic 1000 33%.

The song / Artist with the highest overall vote percentage obtained in this last vote will be proclaimed the Winner of Sanremo 2022.
The second and third song / Artist classified will also be announced.

We want to say thanks to the writer of this post for this awesome content

Sanremo 2022, the regulation. 24 champions in the competition and the “Demoscopica 1.000” arrives among the juries

) [summary] => Sanremo 2022 evenings. The official regulation of the Sanremo Festival. Let’s go immediately to find out what are the main news and how we will vote night by night. Confirmed the number of artists competing. They will be twenty four of which twenty-two chosen by the artistic director Amadeus and two promoted on the field ... Read more [atom_content] =>

Sanremo 2022 evenings. The official regulation of the Sanremo Festival. Let’s go immediately to find out what are the main news and how we will vote night by night.

Confirmed the number of artists competing. They will be twenty four of which twenty-two chosen by the artistic director Amadeus and two promoted on the field the December 15, 2021 gives Sanremo young.

The voting system has been completely renewed with three independent juries with accredited journalists from the press, radio, TV and Web, the confirmation of televoting and the debut of the Demoscopic 1,000.

For all 24 – from Tuesday February 1 live on Rai1, RaiPlay e Radio2 – it will be a race without eliminations to get to the final evening of Saturday 5, with the announcement of the winner.

In addition, the special evening of the Cover di Friday 4th February, during which the artists will perform – alone or with a guest agreed with Rai and with the Artistic Direction – a piece that can be taken not only from the Italian repertoire, but also from the international repertoire of the 60 ‘, 70’ or 80 ‘.

who you can read the regulation Rai in its full version.

Sanremo 2022 evenings: The votes

In the first two evenings, the jury of accredited journalists will vote, divided into three independent voting components: a jury from print and TV, one from radio and one from the web.

In the fourth and fifth evening, however, the Jury of the Press Room, TV, Radio and Web will vote as a single component, joining the Televoting and the Jury 1000 opinion poll, composed of a thousand components selected according to balanced criteria of age and geographical origin, who will vote remotely with an app dedicated to them.

The conduct of the evenings

The conduct of the evenings provides that Tuesday 1 e Wednesday 2 February 12 songs in the competition are performed by the respective 12 Artists who will be voted, separately, by the 3 voting components of the Press, TV, Radio and Web Jury. The percentage weight on the overall result of the vote will be divided as follows: print media and TV 33 percent; 33 percent web jury; radio jury 34 percent.

After the vote, a ranking of the 12 songs / artists performed in each of the two evenings will be drawn up.

In the third evening the 24 artists will propose the 24 songs in the competition that will be voted on by the public through televoting and by the jury 1000 opinion poll which will have an impact on the overall result of 50 percent.

The average between the overall voting percentages obtained by the songs / artists in the evening and those obtained in the previous evenings will determine a new ranking of the 24 songs / artists in the competition.

In the ?Cover? evening by Friday 4th February each of the 24 artists competing, will propose – alone or with a guest – a song from the Italian and international repertoire of the 60 ‘, 70’ and 80 ‘that will be voted by all the juries with a percentage weight of 34% for Televoto ; 33% for the Jury of the Press Room, TV, Radio and Web; and 33% for the 1000 opinion poll.

The average between the overall percentages of votes obtained by the Artists in the evening and those obtained in the previous evenings will determine a new ranking of the 24 songs / Artists in the competition.

Finally, on the final evening, the 24 songs in the competition will be voted on by the public through televoting and the average between the percentages of votes obtained in the evening and those obtained in the previous evenings will determine a new ranking of the 24 songs / artists.

The first three songs in the chart will be repeated through live performance or through audio-video recording. Previous votes will be cleared and a new audience vote will be held with Televoto; of the Press, TV, Radio and Web Jury; and of the Demoscopica 1000, with a percentage weight divided as follows: Televoto 34%: Jury of the Press Room, TV, Radio and Web 33%; Demoscopic 1000 33%.

The song / Artist with the highest overall vote percentage obtained in this last vote will be proclaimed the Winner of Sanremo 2022.
The second and third song / Artist classified will also be announced.

We want to say thanks to the writer of this post for this awesome content

Sanremo 2022, the regulation. 24 champions in the competition and the “Demoscopica 1.000” arrives among the juries

[date_timestamp] => 1635254646 ) [8] => Array ( [title] => Covid: vaccinations and infections ? how common are neurological complications? [link] => https://bofads.com/covid-vaccinations-and-infections-how-common-are-neurological-complications/ [dc] => Array ( [creator] => Pauline Moonlky ) [pubdate] => Tue, 26 Oct 2021 12:58:45 +0000 [category] => SportcommoncomplicationsCovidinfectionsneurologicalvaccinations [guid] => https://bofads.com/?p=3725 [description] => What are the unwanted complications of a vaccination or a SARS-CoV-2 infection? The British research team looked at rare neurological vaccination complications in the specialist magazine “Nature Medicine” – for example certain paralysis and strokes. After the first vaccination in the time window from the beginning of December 2020 to the end of May 2021. ... Read more [content] => Array ( [encoded] =>

What are the unwanted complications of a vaccination or a SARS-CoV-2 infection?

The British research team looked at rare neurological vaccination complications in the specialist magazine “Nature Medicine” – for example certain paralysis and strokes. After the first vaccination in the time window from the beginning of December 2020 to the end of May 2021.

The fundamental problem is that such incidents are so rare that they are not noticed in the registration studies. That’s why it’s important to work with really big numbers. The team led by researchers at Oxford University had figures from all over England available – from over 32 million people who had been vaccinated.

These numbers come from a vaccination database run by the NHS public health system. This contains the vaccination date, vaccine and dose for all vaccinated persons. In addition, data from Scotland were also available, which they evaluated separately. The researchers compared this with hospital data. The special thing about this study is the amount of data, which promises a very reliable result.

(dpa / Patrick Pleul)Why people become infected with the coronavirus despite being vaccinated
Despite a full vaccination, people can become infected with the coronavirus and even get sick. One then speaks of a vaccination breakthrough. The more people are vaccinated, the more their share of new infections grows.

What did you get out of it?

Neurological complications after a Covid-19 vaccination are very rare, but they do exist. The British researchers were able to identify two signals: They were able to link the vaccination with the AstraZeneca vaccine to a higher risk of Guillain-Barré syndrome. And after vaccination with the vaccine from Pfizer / Biontech, there was an increased risk of stroke due to cerebral haemorrhage.

The researchers emphasize that these results do not explain how this connection between vaccinations and complications comes about. So you cannot say what exactly is going on in the body. But you see a connection in your data.

What is Guillain-Barré Syndrome (GBS)?

GBS manifests itself as paralysis, which usually begins in the legs, but then also affects the arms and the face – and in rare cases also the respiratory muscles. GBS occurs three out of four times after certain infections. This then leads to an excessive immune response. This attacks the sheaths of certain nerve fibers so that they can no longer conduct the nerve impulses well.

GBS cases have also been observed in connection with Covid-19. And there were previously reports from India or the UK that GBS appeared after vaccination against Covid-19. So there was already a suspicion. However, these were only individual case reports, not a large-scale study like the current publication in “Nature Medicine”.

Confirmation of a double corona vaccination in the vaccination card and in the Corona warning app on an iPhone.  (picture alliance / Goldmann | Goldmann) (picture alliance / Goldmann | Goldmann)How long does the corona vaccination protection last?
The effect of the corona vaccinations wears off a little over time. That is why the federal government offers endangered groups a third dose. Who will get the booster vaccination and when does it make sense? An overview.

How big is the risk in concrete terms?

In western countries, Guillain-Barré syndrome occurs in 100 to 200 people per ten million people annually. That is the normal average value – without Covid 19 disease and without vaccination. The British research team has now calculated how many additional cases will come after vaccination. And they say: there are 38 cases per ten million people vaccinated with AstraZeneca. In absolute terms there are very few cases, but also not none.

They also saw with the Pfizer / Biontech vaccine that it was associated with an increased risk of stroke due to cerebral haemorrhage. That was 60 cases per 10 million people vaccinated. Only hospital admissions were counted in both cases. That is a methodological limitation. Less severe cases may have occurred, but they did not appear in this study.

    (www.imago-images.de/Daniel Schäfer) (www.imago-images.de/Daniel Schäfer)How harmless corona cold viruses can be useful
How previous infections with harmless cold coronaviruses influence the response to SARS-CoV-2 is being researched in Berlin. The immune system then reacts faster, said researcher Andreas Thiel. However, cross immunity does not protect against infection.

The SARS-CoV-2 virus can also cause severe neurological symptoms. Does the British team provide solid figures here too?

Yes, and they are significantly larger than in the case of vaccination. With regard to Guillain-Barré syndrome, there are 145 additional cases per ten million people after infection, four times more often than with a vaccination.

The research group also found that SARS-CoV-2 infection increases the risk of further neurological symptoms. Examples are: 123 additional cases per ten million for meningitis and nerve tissue damage and 163 additional cases per 10 million for a so-called myasthenic disorder, i.e. impaired signal transmission between nerve and muscle. With all of these complications, the team was unable to establish a link to vaccination.

So: the risk after an infection is greater than after a vaccination. But in both cases the absolute numbers for a neurological complication are very low.

We want to give thanks to the author of this short article for this awesome content

Covid: vaccinations and infections – how common are neurological complications?

) [summary] => What are the unwanted complications of a vaccination or a SARS-CoV-2 infection? The British research team looked at rare neurological vaccination complications in the specialist magazine “Nature Medicine” – for example certain paralysis and strokes. After the first vaccination in the time window from the beginning of December 2020 to the end of May 2021. ... Read more [atom_content] =>

What are the unwanted complications of a vaccination or a SARS-CoV-2 infection?

The British research team looked at rare neurological vaccination complications in the specialist magazine “Nature Medicine” – for example certain paralysis and strokes. After the first vaccination in the time window from the beginning of December 2020 to the end of May 2021.

The fundamental problem is that such incidents are so rare that they are not noticed in the registration studies. That’s why it’s important to work with really big numbers. The team led by researchers at Oxford University had figures from all over England available – from over 32 million people who had been vaccinated.

These numbers come from a vaccination database run by the NHS public health system. This contains the vaccination date, vaccine and dose for all vaccinated persons. In addition, data from Scotland were also available, which they evaluated separately. The researchers compared this with hospital data. The special thing about this study is the amount of data, which promises a very reliable result.

(dpa / Patrick Pleul)Why people become infected with the coronavirus despite being vaccinated
Despite a full vaccination, people can become infected with the coronavirus and even get sick. One then speaks of a vaccination breakthrough. The more people are vaccinated, the more their share of new infections grows.

What did you get out of it?

Neurological complications after a Covid-19 vaccination are very rare, but they do exist. The British researchers were able to identify two signals: They were able to link the vaccination with the AstraZeneca vaccine to a higher risk of Guillain-Barré syndrome. And after vaccination with the vaccine from Pfizer / Biontech, there was an increased risk of stroke due to cerebral haemorrhage.

The researchers emphasize that these results do not explain how this connection between vaccinations and complications comes about. So you cannot say what exactly is going on in the body. But you see a connection in your data.

What is Guillain-Barré Syndrome (GBS)?

GBS manifests itself as paralysis, which usually begins in the legs, but then also affects the arms and the face – and in rare cases also the respiratory muscles. GBS occurs three out of four times after certain infections. This then leads to an excessive immune response. This attacks the sheaths of certain nerve fibers so that they can no longer conduct the nerve impulses well.

GBS cases have also been observed in connection with Covid-19. And there were previously reports from India or the UK that GBS appeared after vaccination against Covid-19. So there was already a suspicion. However, these were only individual case reports, not a large-scale study like the current publication in “Nature Medicine”.

Confirmation of a double corona vaccination in the vaccination card and in the Corona warning app on an iPhone.  (picture alliance / Goldmann | Goldmann) (picture alliance / Goldmann | Goldmann)How long does the corona vaccination protection last?
The effect of the corona vaccinations wears off a little over time. That is why the federal government offers endangered groups a third dose. Who will get the booster vaccination and when does it make sense? An overview.

How big is the risk in concrete terms?

In western countries, Guillain-Barré syndrome occurs in 100 to 200 people per ten million people annually. That is the normal average value – without Covid 19 disease and without vaccination. The British research team has now calculated how many additional cases will come after vaccination. And they say: there are 38 cases per ten million people vaccinated with AstraZeneca. In absolute terms there are very few cases, but also not none.

They also saw with the Pfizer / Biontech vaccine that it was associated with an increased risk of stroke due to cerebral haemorrhage. That was 60 cases per 10 million people vaccinated. Only hospital admissions were counted in both cases. That is a methodological limitation. Less severe cases may have occurred, but they did not appear in this study.

    (www.imago-images.de/Daniel Schäfer) (www.imago-images.de/Daniel Schäfer)How harmless corona cold viruses can be useful
How previous infections with harmless cold coronaviruses influence the response to SARS-CoV-2 is being researched in Berlin. The immune system then reacts faster, said researcher Andreas Thiel. However, cross immunity does not protect against infection.

The SARS-CoV-2 virus can also cause severe neurological symptoms. Does the British team provide solid figures here too?

Yes, and they are significantly larger than in the case of vaccination. With regard to Guillain-Barré syndrome, there are 145 additional cases per ten million people after infection, four times more often than with a vaccination.

The research group also found that SARS-CoV-2 infection increases the risk of further neurological symptoms. Examples are: 123 additional cases per ten million for meningitis and nerve tissue damage and 163 additional cases per 10 million for a so-called myasthenic disorder, i.e. impaired signal transmission between nerve and muscle. With all of these complications, the team was unable to establish a link to vaccination.

So: the risk after an infection is greater than after a vaccination. But in both cases the absolute numbers for a neurological complication are very low.

We want to give thanks to the author of this short article for this awesome content

Covid: vaccinations and infections – how common are neurological complications?

[date_timestamp] => 1635253125 ) [9] => Array ( [title] => Dutch justice orders return of Crimean archaeological treasures to Ukraine [link] => https://bofads.com/dutch-justice-orders-return-of-crimean-archaeological-treasures-to-ukraine/ [dc] => Array ( [creator] => Tom Pauler ) [pubdate] => Tue, 26 Oct 2021 12:45:52 +0000 [category] => NewsarchaeologicalCrimeanDutchjusticereturnTreasuresUkraine [guid] => https://bofads.com/?p=3719 [description] => A piece from the ?Treasures of Crimea?, loaned to a Dutch museum in 2016 by Crimea, a region of Ukraine since annexed by Moscow. PETER DEJONG / AP In the Netherlands, justice ordered on appeal, Tuesday October 26, the return to Ukraine of a collection of archaeological treasures, loaned by Crimea to a museum in ... Read more [content] => Array ( [encoded] =>

In the Netherlands, justice ordered on appeal, Tuesday October 26, the return to Ukraine of a collection of archaeological treasures, loaned by Crimea to a museum in Amsterdam shortly before the annexation of this Ukrainian peninsula by Moscow in 2014. ?The Amsterdam Court of Appeal ordered the Allard Pierson Museum to hand over to the Ukrainian State the ?Crimean treasures? », decided the judges.

Ukrainian President Volodymyr Zelensky on Tuesday welcomed a “Long-awaited victory”. Saying to himself on Twitter ” grateful “ for this “Fair decision”, Mr. Zelensky added that Ukraine “Always get back what belongs to him”, ensuring that after these treasures Kiev “Will recover the Crimea”.

Read also Article reserved for our subscribers Scythian gold, victim of conflict between Moscow and Kiev

In November 2014, four museums in Crimea launched a joint legal action to force the Allard Pierson Museum, archaeological museum of the University of Amsterdam, to return works loaned for the exhibition “The Crimea: gold and secrets of the black Sea “. In 2016, a Dutch court ruled that these archaeological treasures should be returned to Ukraine, explaining that Crimea was not considered an autonomous state.

The museum “between a rock and a hard place”

The Crimean museums then appealed the judgment, arguing that the gold belonged to this region. In 2019, the Amsterdam Court of Appeal stressed that it needed more time to rule. As for the treasures, they were, in the meantime, kept in a “Safe place” by the Allard Pierson Museum. The rich collection of objects, dating from the second century AD until the early Middle Ages, was on loan to this museum less than a month before Russia’s annexation of Crimea, after a military intervention followed by a referendum of attachment deemed illegal by Kiev and the West.

Torn between Ukraine and Crimea, both of which demanded the return of the objects, the Allard Pierson Museum was taken ” between the devil and the deep sea “, had estimated the Dutch court in 2016. Its judgment had caused the anger of Moscow and the joy of Petro Poroshenko, then president of Ukraine. According to him, the decision meant that “Not only is Scythian gold Ukrainian, but also Crimea is Ukrainian”.

Another piece from the ?Treasures of Crimea?, photographed in April 2014.
Read also: Article reserved for our subscribers Travel to Vladimir Putin’s showcase region

It was therefore for the Amsterdam Court of Appeal to decide. Since the case does not appear to be covered by Dutch or European laws, nor to be linked to world heritage as defined by Unesco, it was now, according to this jurisdiction, to “Decide who has the strongest rights”. Andreï Malguine, the director of the Tavrida Museum in Simferopol, one of the four establishments in Crimea to have initiated the legal action, had meanwhile accused the Dutch justice of “Hang out” the trial.

?This question is very complicated. We would of course like our collection to be back in his house ?, for his part declared in September the spokesman of the Kremlin, Dmitry Peskov. “We not only collect museum pieces”, but also “Relics testifying to our millennial history”, for his part commented Tuesday, in a video, the head of the Ukrainian diplomacy, Dmytro Kuleba. During the trial, “All Russian falsifications and manipulations” resulted in a « fiasco », he concluded.

The World with AFP

We would love to say thanks to the author of this write-up for this awesome web content

Dutch justice orders return of Crimean archaeological treasures to Ukraine

) [summary] => A piece from the ?Treasures of Crimea?, loaned to a Dutch museum in 2016 by Crimea, a region of Ukraine since annexed by Moscow. PETER DEJONG / AP In the Netherlands, justice ordered on appeal, Tuesday October 26, the return to Ukraine of a collection of archaeological treasures, loaned by Crimea to a museum in ... Read more [atom_content] =>

In the Netherlands, justice ordered on appeal, Tuesday October 26, the return to Ukraine of a collection of archaeological treasures, loaned by Crimea to a museum in Amsterdam shortly before the annexation of this Ukrainian peninsula by Moscow in 2014. ?The Amsterdam Court of Appeal ordered the Allard Pierson Museum to hand over to the Ukrainian State the ?Crimean treasures? », decided the judges.

Ukrainian President Volodymyr Zelensky on Tuesday welcomed a “Long-awaited victory”. Saying to himself on Twitter ” grateful “ for this “Fair decision”, Mr. Zelensky added that Ukraine “Always get back what belongs to him”, ensuring that after these treasures Kiev “Will recover the Crimea”.

Read also Article reserved for our subscribers Scythian gold, victim of conflict between Moscow and Kiev

In November 2014, four museums in Crimea launched a joint legal action to force the Allard Pierson Museum, archaeological museum of the University of Amsterdam, to return works loaned for the exhibition “The Crimea: gold and secrets of the black Sea “. In 2016, a Dutch court ruled that these archaeological treasures should be returned to Ukraine, explaining that Crimea was not considered an autonomous state.

The museum “between a rock and a hard place”

The Crimean museums then appealed the judgment, arguing that the gold belonged to this region. In 2019, the Amsterdam Court of Appeal stressed that it needed more time to rule. As for the treasures, they were, in the meantime, kept in a “Safe place” by the Allard Pierson Museum. The rich collection of objects, dating from the second century AD until the early Middle Ages, was on loan to this museum less than a month before Russia’s annexation of Crimea, after a military intervention followed by a referendum of attachment deemed illegal by Kiev and the West.

Torn between Ukraine and Crimea, both of which demanded the return of the objects, the Allard Pierson Museum was taken ” between the devil and the deep sea “, had estimated the Dutch court in 2016. Its judgment had caused the anger of Moscow and the joy of Petro Poroshenko, then president of Ukraine. According to him, the decision meant that “Not only is Scythian gold Ukrainian, but also Crimea is Ukrainian”.

Another piece from the ?Treasures of Crimea?, photographed in April 2014.
Read also: Article reserved for our subscribers Travel to Vladimir Putin’s showcase region

It was therefore for the Amsterdam Court of Appeal to decide. Since the case does not appear to be covered by Dutch or European laws, nor to be linked to world heritage as defined by Unesco, it was now, according to this jurisdiction, to “Decide who has the strongest rights”. Andreï Malguine, the director of the Tavrida Museum in Simferopol, one of the four establishments in Crimea to have initiated the legal action, had meanwhile accused the Dutch justice of “Hang out” the trial.

?This question is very complicated. We would of course like our collection to be back in his house ?, for his part declared in September the spokesman of the Kremlin, Dmitry Peskov. “We not only collect museum pieces”, but also “Relics testifying to our millennial history”, for his part commented Tuesday, in a video, the head of the Ukrainian diplomacy, Dmytro Kuleba. During the trial, “All Russian falsifications and manipulations” resulted in a « fiasco », he concluded.

The World with AFP

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Dutch justice orders return of Crimean archaeological treasures to Ukraine

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