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Microsoft releases new Surface devices
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                    [title] => Microsoft releases new Surface devices
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                            [creator] => David Lonit
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                    [pubdate] => Sat, 30 Oct 2021 08:36:52 +0000
                    [category] => GadgetsdevicesreleasesSurface
                    [guid] => https://bofads.com/?p=791
                    [description] => Microsoft is renewing its Surface range. Five new devices, one refreshed device and a range of accessories will be available in Belgium this fall and early 2022 for consumers and/or business users. Surface Pro 8 According to Microsoft, this 13-inch 2-in-1 is twice as fast as the Pro 7 and has an 11th generation Intel ... Read more
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Microsoft is renewing its Surface range. Five new devices, one refreshed device and a range of accessories will be available in Belgium this fall and early 2022 for consumers and/or business users.

Surface Pro 8

According to Microsoft, this 13-inch 2-in-1 is twice as fast as the Pro 7 and has an 11th generation Intel Core processor, two Thunderbolt 4 connections and a 16-hour battery. At the back we find a 10 megapixel 4K camera with Doby Atmos sound, at the back a 5 megapixel camera. It is also possible to place and charge the Surface Slim Pen 2 in the device.

Available in Belgium from early 2022 for 1,249 euros.

Surface Laptop Studio

This 14.4 inch laptop/tablet combination can be in three modes (station mode, stage mode and studio mode), also has room for the Surface Slim Pen 2. Under the hood we find the 11th generation Intel Core H35 processor (i5 or i7 and 1742.9 grams or 1820.2 grams respectively), 16 or 32 GB of RAM. Graphically, we find here a GeForce RTX 3050 Ti GPU with 4 GB of graphics memory.

Available in Belgium from early 2022 for 1,799 euros.

Surface Laptop Studio, Microsoft
Surface Laptop Studio © Microsoft

Surface Go 3

According to Microsoft, the lightest 2-in-1 Surface (544 grams) is sixty percent faster than its predecessor. The device has a 10.5 inch screen with adjustable stand. There is an i3 chip (10th generation) and a 1080p HD camera and optional LTE (4G) at the front and back. Under the hood is 4 or 8 gigabytes of RAM.

Available in Belgium from October 5 from 439 euros.

Surface Go 3, Microsoft
Surface Go 3 © Microsoft

Surface Pro 7+

The Pro 7+ is not a new device, but was only available for business users at the start of this year. From October 5, the device is also for sale for consumers from 949 euros.

Surface Pro X

No major changes with this 2-in-1 with arm chip, but from now on it will be a WiFi-only option (initially also with 4G modem), with a starting price from 949 euros from the beginning of 2022 in our country.

Surface Pro X, Microsoft
Surface Pro X © Microsoft

Surface Duo 2

This small tablet or large phone combines two screens and compared to its predecessor has a larger screen (5.8 inch single or 8.3 inch double), better (4449 mAh) battery and camera and now has 5G. When closed, notifications are shown on the back.

Available in Belgium from 15 November from 1,649 euros.

Surface Duo 2, Microsoft
Surface Duo 2 © Microsoft
Surface Duo 2, Microsoft
Surface Duo 2 © Microsoft

Accessories

The new surface range also comes with three new accessories. The Surface Slim Pen 2 has better interaction feedback and will be on sale for ?129.99 from November 15 (beginning of 2022 in Luxembourg).

Surface Slim Pen 2, Microsoft
Surface Slim Pen 2 © Microsoft

From Surface Adaptive Kit is a set of tools, initially for the visually impaired, that can adapt the Surface for better usability, available in early 2022 for 10.99 euros.

Surface Adaptive Kit, Microsoft
Surface Adaptive Kit © Microsoft

From Ocean Plastic Mouse is a mouse made from twenty percent recycled ocean waste. Available from October 5 for 27.99 euros.

Ocean Plastic Mouse, Microsoft
Ocean Plastic Mouse © Microsoft

From Microsoft Modern USB-C Headset is, as the name implies, a lightweight pair of headphones that will be available for purchase from September 30 for ?61.99.

Microsoft emphasizes in the margins of its launch that everything is ready for Windows 11. Although that is quite obvious since the operating system will appear at the same time as the devices are on the shelves. If you want to view all Surface products in detail, click here view the presentations and all product photos from Microsoft. Fact sheets can also be found with the different hardware details and options of each device.

According to Microsoft, this 13-inch 2-in-1 is twice as fast as the Pro 7 and has an 11th generation Intel Core processor, two Thunderbolt 4 connections and a 16-hour battery. At the back we find a 10 megapixel 4K camera with Doby Atmos sound, at the back a 5 megapixel camera. It is also possible to place and charge the Surface Slim Pen 2 in the device. Available in Belgium from the beginning of 2022 for 1,249 euros. This 14.4 inch laptop/tablet combination can be used in three modes (station mode, stage mode and studio mode), also has room for the Surface Slim Pen 2. Under the hood we find the 11th generation Intel Core H35 processor (i5 or i7 and 1742.9 grams or 1820.2 grams respectively), 16 or 32 GB of RAM. Graphically, we find a GeForce RTX 3050 Ti GPU with 4 GB of graphics memory.Available in Belgium from the beginning of 2022 for 1,799 euros. The lightest 2-in-1 Surface (544 grams) is, according to Microsoft, sixty percent faster than its predecessor. The device has a 10.5 inch screen with adjustable stand. There is an i3 chip (10th generation) and a 1080p HD camera and optional LTE (4G) at the front and back. Under the hood is 4 or 8 gigabytes of RAM.Available in Belgium from 5 October from 439 euros. The Pro 7+ is not a new device, but was only available for business users at the launch at the beginning of this year. From October 5, the device will also be available for consumers from 949 euros. Also with this 2-in-1 with arm chip, no major changes, but from now on a WiFi-only option (initially also with 4G modem), with a starting price from 949 euros from the beginning of 2022 in our country. This small tablet or large phone combines two screens and compared to its predecessor has a larger screen (5.8 inch single or 8.3 inch double), better (4449 mAh) battery and camera and now has 5G. When closed, notifications are shown on the back.Available in Belgium from 15 November from 1,649 euros. The new surface series also comes with three new accessories. The Surface Slim Pen 2 has better interaction feedback and will be available for ?129.99 from November 15 (beginning of 2022 in Luxembourg). early 2022 for 10.99 euros. The Ocean Plastic Mouse is a mouse that is made of twenty percent recycled ocean waste. Available from October 5 for ?27.99.The Microsoft Modern USB-C Headset is, as the name implies, a lightweight headset that will be available from September 30 for ?61.99.Microsoft emphasizes in the margins of its launch that all is ready for Windows 11. Although that is quite obvious since the operating system will appear the same time that the devices are on the shelves. If you want to view all Surface products in detail, you can view the presentations and all product photos from Microsoft here. Fact sheets can also be found with the different hardware details and options of each device.

We wish to thank the author of this post for this incredible web content

Microsoft releases new Surface devices

) [summary] => Microsoft is renewing its Surface range. Five new devices, one refreshed device and a range of accessories will be available in Belgium this fall and early 2022 for consumers and/or business users. Surface Pro 8 According to Microsoft, this 13-inch 2-in-1 is twice as fast as the Pro 7 and has an 11th generation Intel ... Read more [atom_content] =>

Microsoft is renewing its Surface range. Five new devices, one refreshed device and a range of accessories will be available in Belgium this fall and early 2022 for consumers and/or business users.

Surface Pro 8

According to Microsoft, this 13-inch 2-in-1 is twice as fast as the Pro 7 and has an 11th generation Intel Core processor, two Thunderbolt 4 connections and a 16-hour battery. At the back we find a 10 megapixel 4K camera with Doby Atmos sound, at the back a 5 megapixel camera. It is also possible to place and charge the Surface Slim Pen 2 in the device.

Available in Belgium from early 2022 for 1,249 euros.

Surface Laptop Studio

This 14.4 inch laptop/tablet combination can be in three modes (station mode, stage mode and studio mode), also has room for the Surface Slim Pen 2. Under the hood we find the 11th generation Intel Core H35 processor (i5 or i7 and 1742.9 grams or 1820.2 grams respectively), 16 or 32 GB of RAM. Graphically, we find here a GeForce RTX 3050 Ti GPU with 4 GB of graphics memory.

Available in Belgium from early 2022 for 1,799 euros.

Surface Laptop Studio, Microsoft
Surface Laptop Studio © Microsoft

Surface Go 3

According to Microsoft, the lightest 2-in-1 Surface (544 grams) is sixty percent faster than its predecessor. The device has a 10.5 inch screen with adjustable stand. There is an i3 chip (10th generation) and a 1080p HD camera and optional LTE (4G) at the front and back. Under the hood is 4 or 8 gigabytes of RAM.

Available in Belgium from October 5 from 439 euros.

Surface Go 3, Microsoft
Surface Go 3 © Microsoft

Surface Pro 7+

The Pro 7+ is not a new device, but was only available for business users at the start of this year. From October 5, the device is also for sale for consumers from 949 euros.

Surface Pro X

No major changes with this 2-in-1 with arm chip, but from now on it will be a WiFi-only option (initially also with 4G modem), with a starting price from 949 euros from the beginning of 2022 in our country.

Surface Pro X, Microsoft
Surface Pro X © Microsoft

Surface Duo 2

This small tablet or large phone combines two screens and compared to its predecessor has a larger screen (5.8 inch single or 8.3 inch double), better (4449 mAh) battery and camera and now has 5G. When closed, notifications are shown on the back.

Available in Belgium from 15 November from 1,649 euros.

Surface Duo 2, Microsoft
Surface Duo 2 © Microsoft
Surface Duo 2, Microsoft
Surface Duo 2 © Microsoft

Accessories

The new surface range also comes with three new accessories. The Surface Slim Pen 2 has better interaction feedback and will be on sale for ?129.99 from November 15 (beginning of 2022 in Luxembourg).

Surface Slim Pen 2, Microsoft
Surface Slim Pen 2 © Microsoft

From Surface Adaptive Kit is a set of tools, initially for the visually impaired, that can adapt the Surface for better usability, available in early 2022 for 10.99 euros.

Surface Adaptive Kit, Microsoft
Surface Adaptive Kit © Microsoft

From Ocean Plastic Mouse is a mouse made from twenty percent recycled ocean waste. Available from October 5 for 27.99 euros.

Ocean Plastic Mouse, Microsoft
Ocean Plastic Mouse © Microsoft

From Microsoft Modern USB-C Headset is, as the name implies, a lightweight pair of headphones that will be available for purchase from September 30 for ?61.99.

Microsoft emphasizes in the margins of its launch that everything is ready for Windows 11. Although that is quite obvious since the operating system will appear at the same time as the devices are on the shelves. If you want to view all Surface products in detail, click here view the presentations and all product photos from Microsoft. Fact sheets can also be found with the different hardware details and options of each device.

According to Microsoft, this 13-inch 2-in-1 is twice as fast as the Pro 7 and has an 11th generation Intel Core processor, two Thunderbolt 4 connections and a 16-hour battery. At the back we find a 10 megapixel 4K camera with Doby Atmos sound, at the back a 5 megapixel camera. It is also possible to place and charge the Surface Slim Pen 2 in the device. Available in Belgium from the beginning of 2022 for 1,249 euros. This 14.4 inch laptop/tablet combination can be used in three modes (station mode, stage mode and studio mode), also has room for the Surface Slim Pen 2. Under the hood we find the 11th generation Intel Core H35 processor (i5 or i7 and 1742.9 grams or 1820.2 grams respectively), 16 or 32 GB of RAM. Graphically, we find a GeForce RTX 3050 Ti GPU with 4 GB of graphics memory.Available in Belgium from the beginning of 2022 for 1,799 euros. The lightest 2-in-1 Surface (544 grams) is, according to Microsoft, sixty percent faster than its predecessor. The device has a 10.5 inch screen with adjustable stand. There is an i3 chip (10th generation) and a 1080p HD camera and optional LTE (4G) at the front and back. Under the hood is 4 or 8 gigabytes of RAM.Available in Belgium from 5 October from 439 euros. The Pro 7+ is not a new device, but was only available for business users at the launch at the beginning of this year. From October 5, the device will also be available for consumers from 949 euros. Also with this 2-in-1 with arm chip, no major changes, but from now on a WiFi-only option (initially also with 4G modem), with a starting price from 949 euros from the beginning of 2022 in our country. This small tablet or large phone combines two screens and compared to its predecessor has a larger screen (5.8 inch single or 8.3 inch double), better (4449 mAh) battery and camera and now has 5G. When closed, notifications are shown on the back.Available in Belgium from 15 November from 1,649 euros. The new surface series also comes with three new accessories. The Surface Slim Pen 2 has better interaction feedback and will be available for ?129.99 from November 15 (beginning of 2022 in Luxembourg). early 2022 for 10.99 euros. The Ocean Plastic Mouse is a mouse that is made of twenty percent recycled ocean waste. Available from October 5 for ?27.99.The Microsoft Modern USB-C Headset is, as the name implies, a lightweight headset that will be available from September 30 for ?61.99.Microsoft emphasizes in the margins of its launch that all is ready for Windows 11. Although that is quite obvious since the operating system will appear the same time that the devices are on the shelves. If you want to view all Surface products in detail, you can view the presentations and all product photos from Microsoft here. Fact sheets can also be found with the different hardware details and options of each device.

We wish to thank the author of this post for this incredible web content

Microsoft releases new Surface devices

[date_timestamp] => 1635583012 ) [1] => Array ( [title] => The painful marathon of patients with a long Covid [link] => https://bofads.com/the-painful-marathon-of-patients-with-a-long-covid/ [dc] => Array ( [creator] => Paula Hooper ) [pubdate] => Sat, 30 Oct 2021 08:30:52 +0000 [category] => SciencesCovidmarathonpainfulpatients [guid] => https://bofads.com/?p=788 [description] => Professor Dominique Salmon-Ceron, infectious disease specialist at Hôtel-Dieu, examines a patient in Paris, September 6, 2021. MARIN DRIGUEZ FOR “THE WORLD” More than a year and a half after the start of the pandemic, the long Covid remains a mystery. Yet accustomed to observing post-infectious symptoms, the doctors were baffled by the arrival, from May ... Read more [content] => Array ( [encoded] =>

More than a year and a half after the start of the pandemic, the long Covid remains a mystery. Yet accustomed to observing post-infectious symptoms, the doctors were baffled by the arrival, from May 2020, of many patients still presenting a vast clinical picture several weeks after being infected with SARS-CoV-2: fatigue , dyspnea, pain, anosmia, ageusia …

If the specialists see it a little clearer on the contours of the long Covid and note that “The vast majority of patients are improving, many points remain unanswered”, indicates Professor Dominique Salmon-Ceron, infectious disease specialist at Hôtel-Dieu (Assistance publique-Hôpitaux de Paris, AP-HP). She set up one of the first consultations devoted to post-Covid-19, in May 2020 – thus breaking with the position of some doctors who believe that these are psychosomatic manifestations. Patients are still denouncing the fact of not always being taken seriously by the medical profession.

After attending consultations in March, return to Hôtel-Dieu at the beginning of September to assess the progress of patients – including for some, the course looks like a marathon.

A doctor in the corridor of the Hôtel-Dieu, in Paris, on September 6, 2021.

So Salomé, who had come that day for a consultation, complained of a sort of “Brain fog”, ten months after contracting Covid-19, which then resulted in fatigue, headache, anosmia and ageusia, respiratory discomfort. a PET scan, a functional imaging test that measures glucose consumption in the brain, showed moderate hypometabolism in the brainstem, hippocampus, cerebellum, and olfactory bulb.

For this 21-year-old student, in the third year of psychomotricity, “Fatigue is less present, but it remains sustained”. However, Salomé continued her lessons. Ageusia persists, even if the olfaction has returned a little. This summer, after a month of June devoted to its exams, she sometimes slept up to fifteen hours at a stretch. If the respiratory physiotherapist helped her a lot – she resumed running – she still feels this “Chest tightness” and feels out of breath going up three floors.

Mostly women

How many infected people are in the same situation? Difficult to know the exact prevalence of long Covid. “To answer it, he large-scale studies are needed among symptomatic and asymptomatic people in the general population, indicates Dominique Salmon-Ceron. Studies show that about 25% to 30% of patients still have symptoms one to two months after the initial diagnosis and 10% to 15% after six to eight months. “

You have 83.81% of this article to read. The rest is for subscribers only.

We want to give thanks to the author of this article for this outstanding material

The painful marathon of patients with a long Covid

) [summary] => Professor Dominique Salmon-Ceron, infectious disease specialist at Hôtel-Dieu, examines a patient in Paris, September 6, 2021. MARIN DRIGUEZ FOR “THE WORLD” More than a year and a half after the start of the pandemic, the long Covid remains a mystery. Yet accustomed to observing post-infectious symptoms, the doctors were baffled by the arrival, from May ... Read more [atom_content] =>

More than a year and a half after the start of the pandemic, the long Covid remains a mystery. Yet accustomed to observing post-infectious symptoms, the doctors were baffled by the arrival, from May 2020, of many patients still presenting a vast clinical picture several weeks after being infected with SARS-CoV-2: fatigue , dyspnea, pain, anosmia, ageusia …

If the specialists see it a little clearer on the contours of the long Covid and note that “The vast majority of patients are improving, many points remain unanswered”, indicates Professor Dominique Salmon-Ceron, infectious disease specialist at Hôtel-Dieu (Assistance publique-Hôpitaux de Paris, AP-HP). She set up one of the first consultations devoted to post-Covid-19, in May 2020 – thus breaking with the position of some doctors who believe that these are psychosomatic manifestations. Patients are still denouncing the fact of not always being taken seriously by the medical profession.

After attending consultations in March, return to Hôtel-Dieu at the beginning of September to assess the progress of patients – including for some, the course looks like a marathon.

A doctor in the corridor of the Hôtel-Dieu, in Paris, on September 6, 2021.

So Salomé, who had come that day for a consultation, complained of a sort of “Brain fog”, ten months after contracting Covid-19, which then resulted in fatigue, headache, anosmia and ageusia, respiratory discomfort. a PET scan, a functional imaging test that measures glucose consumption in the brain, showed moderate hypometabolism in the brainstem, hippocampus, cerebellum, and olfactory bulb.

For this 21-year-old student, in the third year of psychomotricity, “Fatigue is less present, but it remains sustained”. However, Salomé continued her lessons. Ageusia persists, even if the olfaction has returned a little. This summer, after a month of June devoted to its exams, she sometimes slept up to fifteen hours at a stretch. If the respiratory physiotherapist helped her a lot – she resumed running – she still feels this “Chest tightness” and feels out of breath going up three floors.

Mostly women

How many infected people are in the same situation? Difficult to know the exact prevalence of long Covid. “To answer it, he large-scale studies are needed among symptomatic and asymptomatic people in the general population, indicates Dominique Salmon-Ceron. Studies show that about 25% to 30% of patients still have symptoms one to two months after the initial diagnosis and 10% to 15% after six to eight months. “

You have 83.81% of this article to read. The rest is for subscribers only.

We want to give thanks to the author of this article for this outstanding material

The painful marathon of patients with a long Covid

[date_timestamp] => 1635582652 ) [2] => Array ( [title] => Novel gene therapy platform speeds search for ways to cure blindness [link] => https://bofads.com/novel-gene-therapy-platform-speeds-search-for-ways-to-cure-blindness/ [dc] => Array ( [creator] => Tony Grantly ) [pubdate] => Sat, 30 Oct 2021 08:09:40 +0000 [category] => Health And Scienceblindnesscuregeneplatformsearchspeedstherapy [guid] => https://bofads.com/?p=786 [description] => Journal Reference: Bilge E Öztürk, Molly E Johnson, Michael Kleyman, Serhan Turunç, Jing He, Sara Jabalameli, Zhouhuan Xi, Meike Visel, Valérie L Dufour, Simone Iwabe, Felipe Pompeo Marinho, Gustavo D Aguirre, José-Alain Sahel, David V Schaffer, Andreas R Pfenning, John G Flannery, William A Beltran, William R Stauffer, Leah C Byrne. scAAVengr, a transcriptome-based pipeline ... Read more [content] => Array ( [encoded] =>

Journal Reference:

  1. Bilge E Öztürk, Molly E Johnson, Michael Kleyman, Serhan Turunç, Jing He, Sara Jabalameli, Zhouhuan Xi, Meike Visel, Valérie L Dufour, Simone Iwabe, Felipe Pompeo Marinho, Gustavo D Aguirre, José-Alain Sahel, David V Schaffer, Andreas R Pfenning, John G Flannery, William A Beltran, William R Stauffer, Leah C Byrne. scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution. eLife, 2021; 10 DOI: 10.7554/eLife.64175

The technology, described in a paper published today in the journal eLife, streamlines development of gene therapy approaches for the treatment of genetic blinding disorders. The approach saves precious time and resources by speeding up identification of suitable gene-carrying candidates able to deliver therapy to an affected part of the retina with astounding accuracy.

?Vision loss has a huge impact on quality of life. It has long been near the top of the greatest fears of people, alongside cancer and Alzheimer?s disease,? said senior author Leah Byrne, Ph.D., assistant professor of ophthalmology at Pitt. ?But the field of vision restoration has entered a new era, where many patients have received effective treatment for the very first time. Because of that, the potential of our new platform is thrilling ? it will allow us to translate emergent therapies that are already working for some patients into the clinic much more rapidly.?

Even though blinding genetic disorders that affect the retina are considered rare, approximately 1 in every 3,000 people worldwide carries one or more copies of broken genes that cause retinal degeneration and loss of vision. For centuries, many people with inherited blindness were all but guaranteed to spend a portion of their lives in darkness.

Now, with several gene therapies already on the market in Europe and the U.S., and dozens more entering clinical trials, hope for people with inherited blindness is within reach, but a key obstacle remains: ensuring that vectors, or inactivated viruses carrying the therapeutic genetic code, enter the exact cells that scientists are targeting. The retina is composed of hundreds of millions of cells that are arranged into a series of layers, so precisely targeting the vector to a specific location within that universe is not a trivial task.

To approach the problem, researchers developed a computational platform called scAAVengr, which uses single-cell RNA sequencing to quickly and quantitatively evaluate ? among dozens of options ? which adeno-associated virus vector, or AAV, is best suited for the task of delivering a gene therapy to a specific part of the retina.

The traditional approach of evaluating AAVs is painstakingly slow, requiring several years and many experimental animals. It is also not very precise, since it doesn?t directly measure if AAVs not only entered the cells but also delivered their gene therapy cargo.

In contrast, scAAVengr uses single-cell RNA sequencing, which detects if the cargo arrives at its destination safely. And with scAAVengr, that process takes months, not years.

The platform?s uses aren?t just limited to the retina ? the researchers showed that it works just as well for the identification of AAVs that target other tissues, including the brain, heart and liver.

?A rising tide lifts all boats, and we hope that this technology propels gene therapy treatments not just in the field of vision restoration but for other purposes,? said Byrne. ?Rapidly developing fields of gene editing and optogenetics all rely on efficient gene delivery, so the ability to quickly and strategically choose the delivery vectors would be an exciting leap forward.?

Other authors of this research include Bilge Öztürk, Ph.D., Molly Johnson, B.S., Serhan Turunç, Ph.D., Jing He, B.S., Sara Jabalameli, P.S.M., Zhouhuan Xi, B.S., William R. Stauffer, Ph.D., and José-Alain Sahel, M.D., all of Pitt; Michael Kleyman, Ph.D., and Andreas Pfenning, Ph.D., both of Carnegie Mellon University; Meike Visel, Ph.D., David Schaffer, Ph.D., and John Flannery, Ph.D., all of the University of California Berkeley; Valérie Dufour, Ph.D., Simone Iwabe, Ph.D., Felipe Pompeo Marinho, Ph.D., and Gustavo Aguirre, Ph.D., all of the University of Pennsylvania.

This research was supported by the National Institutes of Health (F32EY023891, R24EY-022012, R01EY017549, P30EY001583, UG3MH120094, DP2MH113095), The UPMC Immune Transplant and Therapy Center, Foundation Fighting Blindness, Ford Foundation, Research to Prevent Blindness and the Van Sloun Fund for Canine Genetic Research.

We want to say thanks to the author of this article for this remarkable content

Novel gene therapy platform speeds search for ways to cure blindness

) [summary] => Journal Reference: Bilge E Öztürk, Molly E Johnson, Michael Kleyman, Serhan Turunç, Jing He, Sara Jabalameli, Zhouhuan Xi, Meike Visel, Valérie L Dufour, Simone Iwabe, Felipe Pompeo Marinho, Gustavo D Aguirre, José-Alain Sahel, David V Schaffer, Andreas R Pfenning, John G Flannery, William A Beltran, William R Stauffer, Leah C Byrne. scAAVengr, a transcriptome-based pipeline ... Read more [atom_content] =>

Journal Reference:

  1. Bilge E Öztürk, Molly E Johnson, Michael Kleyman, Serhan Turunç, Jing He, Sara Jabalameli, Zhouhuan Xi, Meike Visel, Valérie L Dufour, Simone Iwabe, Felipe Pompeo Marinho, Gustavo D Aguirre, José-Alain Sahel, David V Schaffer, Andreas R Pfenning, John G Flannery, William A Beltran, William R Stauffer, Leah C Byrne. scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution. eLife, 2021; 10 DOI: 10.7554/eLife.64175

The technology, described in a paper published today in the journal eLife, streamlines development of gene therapy approaches for the treatment of genetic blinding disorders. The approach saves precious time and resources by speeding up identification of suitable gene-carrying candidates able to deliver therapy to an affected part of the retina with astounding accuracy.

?Vision loss has a huge impact on quality of life. It has long been near the top of the greatest fears of people, alongside cancer and Alzheimer?s disease,? said senior author Leah Byrne, Ph.D., assistant professor of ophthalmology at Pitt. ?But the field of vision restoration has entered a new era, where many patients have received effective treatment for the very first time. Because of that, the potential of our new platform is thrilling ? it will allow us to translate emergent therapies that are already working for some patients into the clinic much more rapidly.?

Even though blinding genetic disorders that affect the retina are considered rare, approximately 1 in every 3,000 people worldwide carries one or more copies of broken genes that cause retinal degeneration and loss of vision. For centuries, many people with inherited blindness were all but guaranteed to spend a portion of their lives in darkness.

Now, with several gene therapies already on the market in Europe and the U.S., and dozens more entering clinical trials, hope for people with inherited blindness is within reach, but a key obstacle remains: ensuring that vectors, or inactivated viruses carrying the therapeutic genetic code, enter the exact cells that scientists are targeting. The retina is composed of hundreds of millions of cells that are arranged into a series of layers, so precisely targeting the vector to a specific location within that universe is not a trivial task.

To approach the problem, researchers developed a computational platform called scAAVengr, which uses single-cell RNA sequencing to quickly and quantitatively evaluate ? among dozens of options ? which adeno-associated virus vector, or AAV, is best suited for the task of delivering a gene therapy to a specific part of the retina.

The traditional approach of evaluating AAVs is painstakingly slow, requiring several years and many experimental animals. It is also not very precise, since it doesn?t directly measure if AAVs not only entered the cells but also delivered their gene therapy cargo.

In contrast, scAAVengr uses single-cell RNA sequencing, which detects if the cargo arrives at its destination safely. And with scAAVengr, that process takes months, not years.

The platform?s uses aren?t just limited to the retina ? the researchers showed that it works just as well for the identification of AAVs that target other tissues, including the brain, heart and liver.

?A rising tide lifts all boats, and we hope that this technology propels gene therapy treatments not just in the field of vision restoration but for other purposes,? said Byrne. ?Rapidly developing fields of gene editing and optogenetics all rely on efficient gene delivery, so the ability to quickly and strategically choose the delivery vectors would be an exciting leap forward.?

Other authors of this research include Bilge Öztürk, Ph.D., Molly Johnson, B.S., Serhan Turunç, Ph.D., Jing He, B.S., Sara Jabalameli, P.S.M., Zhouhuan Xi, B.S., William R. Stauffer, Ph.D., and José-Alain Sahel, M.D., all of Pitt; Michael Kleyman, Ph.D., and Andreas Pfenning, Ph.D., both of Carnegie Mellon University; Meike Visel, Ph.D., David Schaffer, Ph.D., and John Flannery, Ph.D., all of the University of California Berkeley; Valérie Dufour, Ph.D., Simone Iwabe, Ph.D., Felipe Pompeo Marinho, Ph.D., and Gustavo Aguirre, Ph.D., all of the University of Pennsylvania.

This research was supported by the National Institutes of Health (F32EY023891, R24EY-022012, R01EY017549, P30EY001583, UG3MH120094, DP2MH113095), The UPMC Immune Transplant and Therapy Center, Foundation Fighting Blindness, Ford Foundation, Research to Prevent Blindness and the Van Sloun Fund for Canine Genetic Research.

We want to say thanks to the author of this article for this remarkable content

Novel gene therapy platform speeds search for ways to cure blindness

[date_timestamp] => 1635581380 ) [3] => Array ( [title] => In Lebanon, a pivotal year for the education system, threatened with collapse [link] => https://bofads.com/in-lebanon-a-pivotal-year-for-the-education-system-threatened-with-collapse/ [dc] => Array ( [creator] => Paula Hooper ) [pubdate] => Sat, 30 Oct 2021 08:08:51 +0000 [category] => World NewscollapseeducationLebanonpivotalthreatened [guid] => https://bofads.com/?p=783 [description] => In front of a school, in Beirut, September 29, 2021. BILAL HUSSEIN / AP Nour Ezzeddine says it straight away: the private school where she works is privileged. But before the start of the school year, this education advisor from the Elite high school, located near Tire, in southern Lebanon, was tasked with organizing exchanges ... Read more [content] => Array ( [encoded] =>

Nour Ezzeddine says it straight away: the private school where she works is privileged. But before the start of the school year, this education advisor from the Elite high school, located near Tire, in southern Lebanon, was tasked with organizing exchanges of school books, a practice that was extremely rare in the country before the financial debacle started. in the summer of 2019. Without this barter, reinforced by donations of textbooks by the French Embassy, “Many families would have been unable to obtain the books”, Nour adds. As the economic collapse accelerates, the depreciation of the pound is undermining the morale of teachers, whose salaries are hardly worth anything, and the daily hardships endured by families affect students’ concentration. “We cannot give up on education, it is Lebanon’s main strength”, urges the education advisor, who does not escape moments of discouragement.

Read also Article reserved for our subscribers In Lebanon, with those who remain

Education has long been the pride of the country of the Cedars, whose population has the reputation of being the best educated in the Arab world. The quality of the courses given and the importance given to multilingualism have offered generations of Lebanese a key to further studies or well-paid jobs abroad. However, the education system has weakened for more than a decade, for educational and financial reasons. The current cataclysm accentuates these flaws. ?Years of crises, political and social unrest, as well as recent developments in Lebanon have caused the education sector to become largely inefficient and inequitable. It only provides low levels of learning and skills ?, noted, severe, the World Bank in June.

The school year that has opened is considered to be a pivotal one, after two years of teaching very disturbed by the instability that followed the popular uprising of October 2019, then by the Covid-19 pandemic. In 2020, most students only attended face-to-face school for a few weeks. Only a handful of high-end schools have managed to escape the fiasco of online courses, inaccessible to part of the population.

Subsidies from abroad

Historically, private schools, often religious, have always had pride of place. They enrolled more than two-thirds of students in 2018. Tradition has it that many children complete their entire course in the same school, from primary to bac. But these establishments are now faced with the departure of teachers (nearly 10% have left the private sector under the effect of the crisis) but also with the difficulties of parents, in the inability to pay school fees and sometimes forced to switch their child in the public.

You have 57.08% of this article to read. The rest is for subscribers only.

We would love to thank the writer of this post for this remarkable material

In Lebanon, a pivotal year for the education system, threatened with collapse

) [summary] => In front of a school, in Beirut, September 29, 2021. BILAL HUSSEIN / AP Nour Ezzeddine says it straight away: the private school where she works is privileged. But before the start of the school year, this education advisor from the Elite high school, located near Tire, in southern Lebanon, was tasked with organizing exchanges ... Read more [atom_content] =>

Nour Ezzeddine says it straight away: the private school where she works is privileged. But before the start of the school year, this education advisor from the Elite high school, located near Tire, in southern Lebanon, was tasked with organizing exchanges of school books, a practice that was extremely rare in the country before the financial debacle started. in the summer of 2019. Without this barter, reinforced by donations of textbooks by the French Embassy, “Many families would have been unable to obtain the books”, Nour adds. As the economic collapse accelerates, the depreciation of the pound is undermining the morale of teachers, whose salaries are hardly worth anything, and the daily hardships endured by families affect students’ concentration. “We cannot give up on education, it is Lebanon’s main strength”, urges the education advisor, who does not escape moments of discouragement.

Read also Article reserved for our subscribers In Lebanon, with those who remain

Education has long been the pride of the country of the Cedars, whose population has the reputation of being the best educated in the Arab world. The quality of the courses given and the importance given to multilingualism have offered generations of Lebanese a key to further studies or well-paid jobs abroad. However, the education system has weakened for more than a decade, for educational and financial reasons. The current cataclysm accentuates these flaws. ?Years of crises, political and social unrest, as well as recent developments in Lebanon have caused the education sector to become largely inefficient and inequitable. It only provides low levels of learning and skills ?, noted, severe, the World Bank in June.

The school year that has opened is considered to be a pivotal one, after two years of teaching very disturbed by the instability that followed the popular uprising of October 2019, then by the Covid-19 pandemic. In 2020, most students only attended face-to-face school for a few weeks. Only a handful of high-end schools have managed to escape the fiasco of online courses, inaccessible to part of the population.

Subsidies from abroad

Historically, private schools, often religious, have always had pride of place. They enrolled more than two-thirds of students in 2018. Tradition has it that many children complete their entire course in the same school, from primary to bac. But these establishments are now faced with the departure of teachers (nearly 10% have left the private sector under the effect of the crisis) but also with the difficulties of parents, in the inability to pay school fees and sometimes forced to switch their child in the public.

You have 57.08% of this article to read. The rest is for subscribers only.

We would love to thank the writer of this post for this remarkable material

In Lebanon, a pivotal year for the education system, threatened with collapse

[date_timestamp] => 1635581331 ) [4] => Array ( [title] => In Rome, the G20 will have to convince on the climate [link] => https://bofads.com/in-rome-the-g20-will-have-to-convince-on-the-climate/ [dc] => Array ( [creator] => Paula Hooper ) [pubdate] => Sat, 30 Oct 2021 08:01:53 +0000 [category] => PlanetclimateconvinceG20Rome [guid] => https://bofads.com/?p=780 [description] => Italian Prime Minister Mario Draghi (right) greets US President Joe Biden upon his arrival at Palazzo Chigi in Rome on October 29, 2021 ahead of the G20 summit. BRENDAN SMIALOWSKI / AFP They must discuss the fight against Covid-19, the global economic recovery, and especially the climate: the G20 leaders of the world’s largest economies, ... Read more [content] => Array ( [encoded] =>

They must discuss the fight against Covid-19, the global economic recovery, and especially the climate: the G20 leaders of the world’s largest economies, who are meeting from this Saturday, October 30 in Rome, will they be able to send a positive signal just before COP26?

“On all our climate objectives, we have a long way to go and we must step up the pace”, reiterated Friday the Secretary General of the United Nations (UN), Antonio Guterres. It never ceases to warn about the risk of “Climate catastrophe”, pointing the “Special responsibility” G20 countries. This group, which includes the United States, the European Union, but also China, Russia and India, is responsible for the bulk of global emissions. “We still have time to get things back on track, and this G20 meeting is an opportunity to do so”, insisted Mr. Guterres.

Heads of state and government will leave for Glasgow as soon as the G20 summit is completed on Sunday in Rome. However, their ability to agree during this weekend on strong commitments in favor of the climate is not guaranteed. The head of the Italian government, Mario Draghi, had pleaded, at the beginning of October, for “A commitment from the G20 on the need to limit the rise in temperatures to 1.5 degrees”, the most ambitious goal of the Paris Agreement.

“We are not going to stop global warming in Rome or at this COP meeting”, recognized the British Prime Minister, Boris Johnson, on the plane taking him to the Italian capital. “The most we can hope for is to slow down the increase” temperatures. In this context, to what extent are the leaders of the major world economies ready to commit to, for example, abandon coal?

Boris Johnson is said to have insisted again on “The potential exit from coal”, in a telephone conversation on Friday with Chinese President Xi Jinping, who, like his Russian counterpart, Vladimir Putin, will only participate in the G20 by videoconference. Beijing showed a sign of inflection by promising in September to stop building coal-fired power plants abroad. But China, and with it many emerging countries, still depends a lot on this fossil fuel, which emits a lot of CO.2, in particular to run its power plants, in the current context of the energy crisis.

Read also Article reserved for our subscribers A G20 under tension at a time of rivalries exacerbated by the pandemic

The only certainty of concrete progress concerns taxation

In Rome, the subjects of the debt of the poorest countries will also be discussed, and the efforts to be made to vaccinate the planet against Covid-19. On the agenda, it is also planned to address the growing shortages and problems in the global supply chain, which threaten to derail the economic recovery.

The only certainties in terms of concrete progress at the end of this summit with moderate ambitions concern taxation. The G20 should indeed endorse at the highest political level the minimum global taxation at 15% on multinationals. The challenge now is to implement this system in each country, which will reduce the possibilities of tax optimization for multinationals and should bring in 150 billion euros in additional revenue. The stated goal is 2023.

A police officer stands guard outside the

Several demonstrations are planned for Saturday in Rome (unions, extreme left, Fridays for Future), for which thousands of people are expected. More than 5,000 police officers, riflemen and soldiers were mobilized. The Italian capital will be constantly flown over by helicopters and drones, and the district where the summit is held has been “Bunkerized”.

The leaders will also take advantage of their return to a large international meeting – the first time since the start of the pandemic – to increase bilateral or small committee meetings. Joe Biden and Emmanuel Macron, as well as German Chancellor Angela Merkel and British Prime Minister Boris Johnson, want to agree on a resumption of negotiations with Iran.

Emmanuel Macron, who has already staged his reconciliation with Joe Biden on Friday after the submarine affair, also planned to meet Boris Johnson on Sunday, against the backdrop of a crisis between their two countries over post-Brexit fishing. Argentine President Alberto Fernández, for his part, hopes to discuss his debt with IMF Managing Director Kristalina Georgieva.

Read also Article reserved for our subscribers Between Biden and Macron, a difficult reconciliation after the Aukus agreement

The World with AFP

We would like to say thanks to the author of this post for this remarkable material

In Rome, the G20 will have to convince on the climate

) [summary] => Italian Prime Minister Mario Draghi (right) greets US President Joe Biden upon his arrival at Palazzo Chigi in Rome on October 29, 2021 ahead of the G20 summit. BRENDAN SMIALOWSKI / AFP They must discuss the fight against Covid-19, the global economic recovery, and especially the climate: the G20 leaders of the world’s largest economies, ... Read more [atom_content] =>

They must discuss the fight against Covid-19, the global economic recovery, and especially the climate: the G20 leaders of the world’s largest economies, who are meeting from this Saturday, October 30 in Rome, will they be able to send a positive signal just before COP26?

“On all our climate objectives, we have a long way to go and we must step up the pace”, reiterated Friday the Secretary General of the United Nations (UN), Antonio Guterres. It never ceases to warn about the risk of “Climate catastrophe”, pointing the “Special responsibility” G20 countries. This group, which includes the United States, the European Union, but also China, Russia and India, is responsible for the bulk of global emissions. “We still have time to get things back on track, and this G20 meeting is an opportunity to do so”, insisted Mr. Guterres.

Heads of state and government will leave for Glasgow as soon as the G20 summit is completed on Sunday in Rome. However, their ability to agree during this weekend on strong commitments in favor of the climate is not guaranteed. The head of the Italian government, Mario Draghi, had pleaded, at the beginning of October, for “A commitment from the G20 on the need to limit the rise in temperatures to 1.5 degrees”, the most ambitious goal of the Paris Agreement.

“We are not going to stop global warming in Rome or at this COP meeting”, recognized the British Prime Minister, Boris Johnson, on the plane taking him to the Italian capital. “The most we can hope for is to slow down the increase” temperatures. In this context, to what extent are the leaders of the major world economies ready to commit to, for example, abandon coal?

Boris Johnson is said to have insisted again on “The potential exit from coal”, in a telephone conversation on Friday with Chinese President Xi Jinping, who, like his Russian counterpart, Vladimir Putin, will only participate in the G20 by videoconference. Beijing showed a sign of inflection by promising in September to stop building coal-fired power plants abroad. But China, and with it many emerging countries, still depends a lot on this fossil fuel, which emits a lot of CO.2, in particular to run its power plants, in the current context of the energy crisis.

Read also Article reserved for our subscribers A G20 under tension at a time of rivalries exacerbated by the pandemic

The only certainty of concrete progress concerns taxation

In Rome, the subjects of the debt of the poorest countries will also be discussed, and the efforts to be made to vaccinate the planet against Covid-19. On the agenda, it is also planned to address the growing shortages and problems in the global supply chain, which threaten to derail the economic recovery.

The only certainties in terms of concrete progress at the end of this summit with moderate ambitions concern taxation. The G20 should indeed endorse at the highest political level the minimum global taxation at 15% on multinationals. The challenge now is to implement this system in each country, which will reduce the possibilities of tax optimization for multinationals and should bring in 150 billion euros in additional revenue. The stated goal is 2023.

A police officer stands guard outside the

Several demonstrations are planned for Saturday in Rome (unions, extreme left, Fridays for Future), for which thousands of people are expected. More than 5,000 police officers, riflemen and soldiers were mobilized. The Italian capital will be constantly flown over by helicopters and drones, and the district where the summit is held has been “Bunkerized”.

The leaders will also take advantage of their return to a large international meeting – the first time since the start of the pandemic – to increase bilateral or small committee meetings. Joe Biden and Emmanuel Macron, as well as German Chancellor Angela Merkel and British Prime Minister Boris Johnson, want to agree on a resumption of negotiations with Iran.

Emmanuel Macron, who has already staged his reconciliation with Joe Biden on Friday after the submarine affair, also planned to meet Boris Johnson on Sunday, against the backdrop of a crisis between their two countries over post-Brexit fishing. Argentine President Alberto Fernández, for his part, hopes to discuss his debt with IMF Managing Director Kristalina Georgieva.

Read also Article reserved for our subscribers Between Biden and Macron, a difficult reconciliation after the Aukus agreement

The World with AFP

We would like to say thanks to the author of this post for this remarkable material

In Rome, the G20 will have to convince on the climate

[date_timestamp] => 1635580913 ) [5] => Array ( [title] => At the G20, an international of parliamentarians against Beijing [link] => https://bofads.com/at-the-g20-an-international-of-parliamentarians-against-beijing/ [dc] => Array ( [creator] => Paula Hooper ) [pubdate] => Sat, 30 Oct 2021 07:27:05 +0000 [category] => World NewsBeijingG20internationalparliamentarians [guid] => https://bofads.com/?p=777 [description] => The first meeting of the IPAC, led by former British Conservative leader Iain Duncan Smith, in Rome on October 29, 2021. IPAC GLOBAL / YOUTUBE She did not miss any of the subjects that sparked Beijing’s wrath. Freedoms trampled upon in Hong Kong, about which former student leader Nathan Law came to speak. Occupied Tibet, ... Read more [content] => Array ( [encoded] =>

She did not miss any of the subjects that sparked Beijing’s wrath. Freedoms trampled upon in Hong Kong, about which former student leader Nathan Law came to speak. Occupied Tibet, represented by the President of the Central Administration in exile, Penpa Tsering. The persecution of Uighur Muslims in China, evoked by activist musician Rahima Mahmut. Finally, the threats against democratic Taiwan, recalled with clarity in videoconference by its Minister of Foreign Affairs, Joseph Wu.

Read also Article reserved for our subscribers Group of Western parliamentarians attacks China over sterilization of Uighurs

For its first meeting, Friday, October 29, in Rome, the Inter-Parliamentary Alliance on China (IPAC) hit hard. This network of some 200 deputies and senators from all sides and from many countries was born in 2020, on June 4, the anniversary of the Tiananmen repression.

On Friday, the IPAC received the support of Taiwanese Minister Joseph Wu, whose presence in Brussels, unconfirmed, provoked the uneasy runaway of the chanceries. “IPAC is going in the right direction, did he declare. Likewise, the European Union [UE] has pledged to strengthen its political ties with Taiwan, which is a historic milestone. The European Commission has also shown its support. We must continue. “

Read also Article reserved for our subscribers Around Taiwan, China is stepping up its air force demonstrations

The representative of Taipei recalled the Chinese army’s record military incursions into the island’s defense area this year, the relentless political pressure. ?China is trying to destroy democracy. Taiwan is on the front lines. We must not let this happen. I encourage parliamentarians to come. ” With him, this week, two other Taiwanese ministers and business leaders were received in the Czech Republic. Wu stressed that his government was encouraging investment in Europe, especially since the freezing of the EU-China trade agreement, the fate of which has been plagued by the sanctions taken by China against European parliamentarians, in response. to those decided by the EU in support of the Uighurs. “In doing so, China has only strengthened our resolve on human rights”, notes the Belgian deputy Samuel Cogolati, targeted by Beijing.

Read also Article reserved for our subscribers Uighurs: European Union “targeted sanctions” provoke Chinese response

“It is up to Parliaments to act”

The IPAC took advantage of the G20, which met this weekend in the Italian capital, even if it remains lucid about its ability to be heard there, as the British conservative Iain Duncan Smith underlined. This Brexit figure, maker of Boris Johnson’s campaign in 2019, regrets seeing China “Treated like a normal nation in the G20, despite practicing large-scale human rights abuses.” And to add, to the address of the heads of state: ?Just because you don’t want to talk about it doesn’t mean these problems will go away! “

You have 49.05% of this article to read. The rest is for subscribers only.

We wish to thank the author of this short article for this incredible content

At the G20, an international of parliamentarians against Beijing

) [summary] => The first meeting of the IPAC, led by former British Conservative leader Iain Duncan Smith, in Rome on October 29, 2021. IPAC GLOBAL / YOUTUBE She did not miss any of the subjects that sparked Beijing’s wrath. Freedoms trampled upon in Hong Kong, about which former student leader Nathan Law came to speak. Occupied Tibet, ... Read more [atom_content] =>

She did not miss any of the subjects that sparked Beijing’s wrath. Freedoms trampled upon in Hong Kong, about which former student leader Nathan Law came to speak. Occupied Tibet, represented by the President of the Central Administration in exile, Penpa Tsering. The persecution of Uighur Muslims in China, evoked by activist musician Rahima Mahmut. Finally, the threats against democratic Taiwan, recalled with clarity in videoconference by its Minister of Foreign Affairs, Joseph Wu.

Read also Article reserved for our subscribers Group of Western parliamentarians attacks China over sterilization of Uighurs

For its first meeting, Friday, October 29, in Rome, the Inter-Parliamentary Alliance on China (IPAC) hit hard. This network of some 200 deputies and senators from all sides and from many countries was born in 2020, on June 4, the anniversary of the Tiananmen repression.

On Friday, the IPAC received the support of Taiwanese Minister Joseph Wu, whose presence in Brussels, unconfirmed, provoked the uneasy runaway of the chanceries. “IPAC is going in the right direction, did he declare. Likewise, the European Union [UE] has pledged to strengthen its political ties with Taiwan, which is a historic milestone. The European Commission has also shown its support. We must continue. “

Read also Article reserved for our subscribers Around Taiwan, China is stepping up its air force demonstrations

The representative of Taipei recalled the Chinese army’s record military incursions into the island’s defense area this year, the relentless political pressure. ?China is trying to destroy democracy. Taiwan is on the front lines. We must not let this happen. I encourage parliamentarians to come. ” With him, this week, two other Taiwanese ministers and business leaders were received in the Czech Republic. Wu stressed that his government was encouraging investment in Europe, especially since the freezing of the EU-China trade agreement, the fate of which has been plagued by the sanctions taken by China against European parliamentarians, in response. to those decided by the EU in support of the Uighurs. “In doing so, China has only strengthened our resolve on human rights”, notes the Belgian deputy Samuel Cogolati, targeted by Beijing.

Read also Article reserved for our subscribers Uighurs: European Union “targeted sanctions” provoke Chinese response

“It is up to Parliaments to act”

The IPAC took advantage of the G20, which met this weekend in the Italian capital, even if it remains lucid about its ability to be heard there, as the British conservative Iain Duncan Smith underlined. This Brexit figure, maker of Boris Johnson’s campaign in 2019, regrets seeing China “Treated like a normal nation in the G20, despite practicing large-scale human rights abuses.” And to add, to the address of the heads of state: ?Just because you don’t want to talk about it doesn’t mean these problems will go away! “

You have 49.05% of this article to read. The rest is for subscribers only.

We wish to thank the author of this short article for this incredible content

At the G20, an international of parliamentarians against Beijing

[date_timestamp] => 1635578825 ) [6] => Array ( [title] => the professional Smart Home solution ready for IoT [link] => https://bofads.com/the-professional-smart-home-solution-ready-for-iot/ [dc] => Array ( [creator] => David Lonit ) [pubdate] => Sat, 30 Oct 2021 07:25:27 +0000 [category] => GadgetsIoTprofessionalreadySmartsolution [guid] => https://bofads.com/?p=774 [description] => Dovit, manufacturer of the DOVIT home automation platform, is pleased to announce that the professional system for Smart Home DOVIT And compatible with Google Home, Amazon Alexa, Telegram and IFTTT. Choosing a DOVIT home automation system for your real estate projects means offering future buyers not only an efficient, reliable and safe solution, but also ... Read more [content] => Array ( [encoded] =>

Dovit, manufacturer of the DOVIT home automation platform, is pleased to announce that the professional system for Smart Home DOVIT And compatible with Google Home, Amazon Alexa, Telegram and IFTTT.

Choosing a DOVIT home automation system for your real estate projects means offering future buyers not only an efficient, reliable and safe solution, but also a scalable solution open to the world of connected objects … the ideal link between a reliable system and the satisfaction of the most demanding users.

Discover the new IoT products!

Manage your Dovit home with Google Home and Amazon Alexa voice control
The owners of the DOVIT Smart Home can control all the scenarios, and therefore all the functions present in their home automation system, with simplicity and reliability.

A solution undoubtedly quick and useful to check your home. Imagine walking into the house with your hands full and being able to turn on the light with your voice or turn down the volume of the music when your phone rings. Imagine the indisputable advantage for all people who have motor disabilities.

Google Home
Control the lights and all other scenarios, created by the Dovit application, with your voice. The commands can be given through the “smart speakers” or by interacting directly with the voice control from your smart phone.

“Ok Google, turn on the living room light”
“Ok Google, activate the night scenario”

Amazon Alexa
Control the lighting and scenarios, created by the Dovit application, with your voice through the speakers connected to Amazon Alexa or by interacting with the Alexa application.

“Alexa, turn off the light in the kitchen”
“Alexa, activate open all shutters”

Personalize your daily life with Google Home and Amazon Alexa

The dialogue between the voice assistants and the DOVIT Smart Home functions can be customized at any time.

For example, if the “close all roller shutters”, “turn off all lights” and “lower the temperature by one degree” scenarios have been created from the Dovit application, you can link all of them these actions at a simple command like: ?Alexa, I’m going out? or ?Ok Google, good night? and all the chosen functions will be recalled!

From the point of view of safety, at any time it is possible to disable some functions or the complete connection with a service. Also, to link a voice assistant account to your DOVIT Smart Home, explicit authorization from the home touch screen is required in order to ensure that the association was really requested by the owner.

With Telegram you receive “push” notifications without having the Dovit app always active and command the scenarios with simple messages

Telegram is an instant messaging application that allows the user to receive all “push” notifications from their home automation system directly on the Telegram application. The Dovit home automation system can send, for example, notifications from the alarm system, from the maintenance system or simply notify you every time a specific door is opened.

Furthermore, through Telegram it is possible to control each scenario simply by writing a message to your Smart Home.

Control connected objects or create your own automations with IFTTT
Any device or scenario connected to the DOVIT Smart Home system can be defined as a ?That? action to be performed through the IFTTT ?Webhooks? service.

A few examples:

IFTTT integrates many systems that can be viewed on: https://ifttt.com/services

Compatibility required:
To install the DOVIT IoT activation licenses it is necessary to have a Smart Home system with a server version V.3.73 or later and a version of the Dovit application 1.73 or later as well as a smartphone with the Dovit application or a touch screen wall mounted Dovit.

The other prerequisites are: have a Dovit account, activated remote control and have an Internet connection, to use the Amazon Alexa or Google Assistant voice assistants, you need a standard Google or Amazon Alexa user account and a device that supports Alexa or Google Home.


WHO IS DOVIT?

DOVIT is a multinational present in Italy (Dovit Italia) and in other European countries. The DOVIT project was born in 2016 from the collaboration and subsequent merger between Home Innovation (Italian manufacturer of the already well-known integration platform Hi System) and one of the main European real estate leaders, Promobe SA. Together in 2016 they created the largest “smart” neighborhood in Europe: the “Cloche d’Or” in Luxembourg. From this common project and the desire to offer modern and integrated ?Smart home? solutions, on a large scale? the company DOVIT and the homonymous ecosystem for the Smart Home are born. Dovit is an open platform that integrates all the technological areas of the modern home in a single system with attention to ease of use and product design.

For more information:
www.dovit.com

Print Friendly, PDF & Email

We would like to say thanks to the writer of this short article for this awesome content

the professional Smart Home solution ready for IoT

) [summary] => Dovit, manufacturer of the DOVIT home automation platform, is pleased to announce that the professional system for Smart Home DOVIT And compatible with Google Home, Amazon Alexa, Telegram and IFTTT. Choosing a DOVIT home automation system for your real estate projects means offering future buyers not only an efficient, reliable and safe solution, but also ... Read more [atom_content] =>

Dovit, manufacturer of the DOVIT home automation platform, is pleased to announce that the professional system for Smart Home DOVIT And compatible with Google Home, Amazon Alexa, Telegram and IFTTT.

Choosing a DOVIT home automation system for your real estate projects means offering future buyers not only an efficient, reliable and safe solution, but also a scalable solution open to the world of connected objects … the ideal link between a reliable system and the satisfaction of the most demanding users.

Discover the new IoT products!

Manage your Dovit home with Google Home and Amazon Alexa voice control
The owners of the DOVIT Smart Home can control all the scenarios, and therefore all the functions present in their home automation system, with simplicity and reliability.

A solution undoubtedly quick and useful to check your home. Imagine walking into the house with your hands full and being able to turn on the light with your voice or turn down the volume of the music when your phone rings. Imagine the indisputable advantage for all people who have motor disabilities.

Google Home
Control the lights and all other scenarios, created by the Dovit application, with your voice. The commands can be given through the “smart speakers” or by interacting directly with the voice control from your smart phone.

“Ok Google, turn on the living room light”
“Ok Google, activate the night scenario”

Amazon Alexa
Control the lighting and scenarios, created by the Dovit application, with your voice through the speakers connected to Amazon Alexa or by interacting with the Alexa application.

“Alexa, turn off the light in the kitchen”
“Alexa, activate open all shutters”

Personalize your daily life with Google Home and Amazon Alexa

The dialogue between the voice assistants and the DOVIT Smart Home functions can be customized at any time.

For example, if the “close all roller shutters”, “turn off all lights” and “lower the temperature by one degree” scenarios have been created from the Dovit application, you can link all of them these actions at a simple command like: ?Alexa, I’m going out? or ?Ok Google, good night? and all the chosen functions will be recalled!

From the point of view of safety, at any time it is possible to disable some functions or the complete connection with a service. Also, to link a voice assistant account to your DOVIT Smart Home, explicit authorization from the home touch screen is required in order to ensure that the association was really requested by the owner.

With Telegram you receive “push” notifications without having the Dovit app always active and command the scenarios with simple messages

Telegram is an instant messaging application that allows the user to receive all “push” notifications from their home automation system directly on the Telegram application. The Dovit home automation system can send, for example, notifications from the alarm system, from the maintenance system or simply notify you every time a specific door is opened.

Furthermore, through Telegram it is possible to control each scenario simply by writing a message to your Smart Home.

Control connected objects or create your own automations with IFTTT
Any device or scenario connected to the DOVIT Smart Home system can be defined as a ?That? action to be performed through the IFTTT ?Webhooks? service.

A few examples:

IFTTT integrates many systems that can be viewed on: https://ifttt.com/services

Compatibility required:
To install the DOVIT IoT activation licenses it is necessary to have a Smart Home system with a server version V.3.73 or later and a version of the Dovit application 1.73 or later as well as a smartphone with the Dovit application or a touch screen wall mounted Dovit.

The other prerequisites are: have a Dovit account, activated remote control and have an Internet connection, to use the Amazon Alexa or Google Assistant voice assistants, you need a standard Google or Amazon Alexa user account and a device that supports Alexa or Google Home.


WHO IS DOVIT?

DOVIT is a multinational present in Italy (Dovit Italia) and in other European countries. The DOVIT project was born in 2016 from the collaboration and subsequent merger between Home Innovation (Italian manufacturer of the already well-known integration platform Hi System) and one of the main European real estate leaders, Promobe SA. Together in 2016 they created the largest “smart” neighborhood in Europe: the “Cloche d’Or” in Luxembourg. From this common project and the desire to offer modern and integrated ?Smart home? solutions, on a large scale? the company DOVIT and the homonymous ecosystem for the Smart Home are born. Dovit is an open platform that integrates all the technological areas of the modern home in a single system with attention to ease of use and product design.

For more information:
www.dovit.com

Print Friendly, PDF & Email

We would like to say thanks to the writer of this short article for this awesome content

the professional Smart Home solution ready for IoT

[date_timestamp] => 1635578727 ) [7] => Array ( [title] => Ribom?s money rain in ?wrong? sport: ?Very much worth it? [link] => https://bofads.com/riboms-money-rain-in-wrong-sport-very-much-worth-it/ [dc] => Array ( [creator] => Tim Hall ) [pubdate] => Sat, 30 Oct 2021 07:23:56 +0000 [category] => SportmoneyrainRibomssportworthwrong [guid] => https://bofads.com/?p=771 [description] => Published: Just now VAL SENALES. Emma Ribom, 23, drove in more prize money in a couple of competitions in roller skis this summer than she earned in total during the World Cup circus last year. Now the cross-country skier has hired his former apartment neighbor to take the next step in his career. – I ... Read more [content] => Array ( [encoded] =>

VAL SENALES. Emma Ribom, 23, drove in more prize money in a couple of competitions in roller skis this summer than she earned in total during the World Cup circus last year.

Now the cross-country skier has hired his former apartment neighbor to take the next step in his career.

– I felt that it could be nice with a little relief, says the 23-year-old.

Emma Ribom has somewhat in the shadows established itself at a high level in the national team and achieved good results during last year’s season both on shorter and longer distances.

She sees herself as an all-rounder. A picture national team mate Jonna Sundling shares.

– Emma is a cruel skier and has really had a super nice summer and autumn. She is both very enduring and can also ride very fast, which means that she rides both well on the longer distances but also on sprints, Sundling praises.

SEK 95,000

During this year’s pre-season, the 23-year-old has also impressed. In total, she won four roller ski races this summer and then won a total of approximately SEK 95,000 in prize money.

– I had a really nice weekend in Trollhättan at the Alliance race and was in very good summer shape. It was almost like I was worried that the form had come too soon. So it was super fun to compete and I probably surprised myself very much when I managed to win all three races there. It was a nice receipt to bring with you before the autumn, she says.

To put the sum in perspective, for example, it is more than the total of SEK 77,500 that she earned in total last year in the World Cup.

Important addition to the coffers for a career that is still just in its infancy.

– Yes, God. My ski investment should go around financially, so every little money in is very important to get an elite investment to go around. So of course it was very much worth it.

His former neighbor as manager

As a step in her development, Emma Ribom has during the autumn hired a manager for her stable, which until then consisted only of herself.

– It was actually my old neighbor in Umeå, Erik, who held me a few times in the stairwell and asked if we would not cooperate. He said he could help me and that’s great fun. At first I was a bit skeptical and that is something I wanted to take care of myself. But then last spring we talked and then I said that now we drive. It has been super fun and it is a security that it is a person I lived next door to and played a few rounds of games with back home. I already know him so it feels good to start that collaboration.

Erik Liljestrand, as he is called, will primarily keep in touch with companies and sponsors.

? I felt that it could be nice to have some relief there and have a person who can help me with those contacts. Then I also took the opportunity to hear from my friends about how they work. It is very common to have someone who helps you and can relieve you in such contexts. It felt like a natural step somewhere.

Is it also a final receipt that you have established yourself at the top?

– I do not know if I see it that way, but of course it is a step in my skiing career to have someone rowing with it.

Published:

We would like to thank the writer of this post for this awesome content

Ribom’s money rain in “wrong” sport: “Very much worth it”

) [summary] => Published: Just now VAL SENALES. Emma Ribom, 23, drove in more prize money in a couple of competitions in roller skis this summer than she earned in total during the World Cup circus last year. Now the cross-country skier has hired his former apartment neighbor to take the next step in his career. – I ... Read more [atom_content] =>

VAL SENALES. Emma Ribom, 23, drove in more prize money in a couple of competitions in roller skis this summer than she earned in total during the World Cup circus last year.

Now the cross-country skier has hired his former apartment neighbor to take the next step in his career.

– I felt that it could be nice with a little relief, says the 23-year-old.

Emma Ribom has somewhat in the shadows established itself at a high level in the national team and achieved good results during last year’s season both on shorter and longer distances.

She sees herself as an all-rounder. A picture national team mate Jonna Sundling shares.

– Emma is a cruel skier and has really had a super nice summer and autumn. She is both very enduring and can also ride very fast, which means that she rides both well on the longer distances but also on sprints, Sundling praises.

SEK 95,000

During this year’s pre-season, the 23-year-old has also impressed. In total, she won four roller ski races this summer and then won a total of approximately SEK 95,000 in prize money.

– I had a really nice weekend in Trollhättan at the Alliance race and was in very good summer shape. It was almost like I was worried that the form had come too soon. So it was super fun to compete and I probably surprised myself very much when I managed to win all three races there. It was a nice receipt to bring with you before the autumn, she says.

To put the sum in perspective, for example, it is more than the total of SEK 77,500 that she earned in total last year in the World Cup.

Important addition to the coffers for a career that is still just in its infancy.

– Yes, God. My ski investment should go around financially, so every little money in is very important to get an elite investment to go around. So of course it was very much worth it.

His former neighbor as manager

As a step in her development, Emma Ribom has during the autumn hired a manager for her stable, which until then consisted only of herself.

– It was actually my old neighbor in Umeå, Erik, who held me a few times in the stairwell and asked if we would not cooperate. He said he could help me and that’s great fun. At first I was a bit skeptical and that is something I wanted to take care of myself. But then last spring we talked and then I said that now we drive. It has been super fun and it is a security that it is a person I lived next door to and played a few rounds of games with back home. I already know him so it feels good to start that collaboration.

Erik Liljestrand, as he is called, will primarily keep in touch with companies and sponsors.

? I felt that it could be nice to have some relief there and have a person who can help me with those contacts. Then I also took the opportunity to hear from my friends about how they work. It is very common to have someone who helps you and can relieve you in such contexts. It felt like a natural step somewhere.

Is it also a final receipt that you have established yourself at the top?

– I do not know if I see it that way, but of course it is a step in my skiing career to have someone rowing with it.

Published:

We would like to thank the writer of this post for this awesome content

Ribom’s money rain in “wrong” sport: “Very much worth it”

[date_timestamp] => 1635578636 ) [8] => Array ( [title] => FAMOUS ALBUM: In the heavy metal kitchen Judas Priest cooked ?British Steel?, a work that kicked off their career and became a role model [link] => https://bofads.com/famous-album-in-the-heavy-metal-kitchen-judas-priest-cooked-british-steel-a-work-that-kicked-off-their-career-and-became-a-role-model/ [dc] => Array ( [creator] => Paula Hooper ) [pubdate] => Sat, 30 Oct 2021 07:21:40 +0000 [category] => MusicalbumBritishcareercookedFAMOUSheavyJudaskickedkitchenmetalmodelPriestroleSteel [guid] => https://bofads.com/?p=768 [description] => Some records will fall, some will become commercial masters, and some will be sworn by generations of other musicians. Undoubtedly, “British Steel” by Judas Priest belongs to the latter set. One of the most key recordings of hard music in general has become the theme of our cycle Famous Albums. Birmingham, an industrial city in ... Read more [content] => Array ( [encoded] =>

Some records will fall, some will become commercial masters, and some will be sworn by generations of other musicians. Undoubtedly, “British Steel” by Judas Priest belongs to the latter set. One of the most key recordings of hard music in general has become the theme of our cycle Famous Albums.

Birmingham, an industrial city in central England, could de facto be considered the birthplace of heavy metal. The foundations were laid here by the legendary Black Sabbath, when in 1970 they released their nameless debut. And it was on their music that another band from this city of steelworks and factories built, Judas Priest, which ten years after Sabatech launched “British Steel” and set a model for what heavy metal would look like in the 1980s.

To your definitive expression Judas they went through five decent lines and changes in visual style. “British Steel” brought a sharp sound, a double string of guitars, anthemic melodies – but also leather suits, metal studs and nails, which in turn inspired others. “It’s a clear declaration of the rock way of life,” characterizes the record in the documentary Famous Albums by guitarist Glenn Tipton. “Britih Steel” is still relevant today. Topics like frustration with “Breaking The Law”, the power of the community (“United”) or a theme as common in rock music as “Night After Midnight” still resonate – especially in such a catchy way. what the group, which had to wait for mainstream success, presented them. Although “British Steel” may seem like a straightforward and, in fact, very typical heavy metal recording over time, a number of experimental details will come to the surface when listened to carefully. “We tried everything,” lists Tipton. “At Judas Priest, we’ve always been willing to experiment, and we’ve always tried to push the boundaries of metal to make it more bearable. That’s why people may have called us metal ambassadors.” And so, instead of a whip, it sounds like a string swinging on the kitchen counter, instead of a police siren, a guitar and stomping metal monsters in “Metal Gods” have replaced cutlery drawers. Methods that nowadays, full of samples from the Internet, seem comically woody.

It is worth asking to what extent the sound and the experimental nature of the work were influenced by the place where it originated. The original studio disappointed, so the group rented a country house in Tittenhurst Park to shoot. It belonged to The Beatles drummer Ringo Starr, who bought it from John Lennon. However, it didn’t look the best at first and the band decided to literally play the whole house.

“We started preparing the studio,” describes producer Tom Allom, “But it was quite small and everything sounded flat. We soon realized that we were not able to achieve the desired sound, so we decided, knowing that it would make communication between the control room and the musicians difficult, use the space of the whole house.”

Bassist Ian Hill adds: “We had the advantage that there were dozens of rooms and you could stick wires everywhere in the socket. You could easily record the guitar in the bathroom. Each room had a different acoustics. So you had a variety of sound palettes to choose from.”

The concentrated heavy metal essence hit the time well. Punk was at the zenith, and some of the youth who refused to play synth-pop immediately clapped after “British Steel”. For Judas Priest, the golden age began, when the months spent on tour alternated with time in the studio. More great records were waiting for them, but the influence of this one the purest British steel is by far the largest.

“It’s absolutely beautiful that Judas Priest has become the godfather of modern heavy metal,” the second guitarist KK Downing does not hide his enthusiasm. And singer Rob Halford adds: “The album ‘British Steel’, given its importance, is a universal key that unlocks all the other doors. It’s wonderful that Judas Priest’s legacy remains intact. It’s still a very important band with something to say and a massive fan base. Worldwide.”

A detailed look at the shooting of “British Steel” and spicy stories from behind the scenes was brought by another part of the Famous Albums series. On Friday, October 29, it was broadcast by ?T art. For a week, the cycle continues with the story of Frank Zappa’s “Apostrophe” and “Over-Nite Sensation”.

A series of articles is created in cooperation with Czech Television.

We would like to say thanks to the author of this write-up for this amazing content

FAMOUS ALBUM: In the heavy metal kitchen Judas Priest cooked “British Steel”, a work that kicked off their career and became a role model

) [summary] => Some records will fall, some will become commercial masters, and some will be sworn by generations of other musicians. Undoubtedly, “British Steel” by Judas Priest belongs to the latter set. One of the most key recordings of hard music in general has become the theme of our cycle Famous Albums. Birmingham, an industrial city in ... Read more [atom_content] =>

Some records will fall, some will become commercial masters, and some will be sworn by generations of other musicians. Undoubtedly, “British Steel” by Judas Priest belongs to the latter set. One of the most key recordings of hard music in general has become the theme of our cycle Famous Albums.

Birmingham, an industrial city in central England, could de facto be considered the birthplace of heavy metal. The foundations were laid here by the legendary Black Sabbath, when in 1970 they released their nameless debut. And it was on their music that another band from this city of steelworks and factories built, Judas Priest, which ten years after Sabatech launched “British Steel” and set a model for what heavy metal would look like in the 1980s.

To your definitive expression Judas they went through five decent lines and changes in visual style. “British Steel” brought a sharp sound, a double string of guitars, anthemic melodies – but also leather suits, metal studs and nails, which in turn inspired others. “It’s a clear declaration of the rock way of life,” characterizes the record in the documentary Famous Albums by guitarist Glenn Tipton. “Britih Steel” is still relevant today. Topics like frustration with “Breaking The Law”, the power of the community (“United”) or a theme as common in rock music as “Night After Midnight” still resonate – especially in such a catchy way. what the group, which had to wait for mainstream success, presented them. Although “British Steel” may seem like a straightforward and, in fact, very typical heavy metal recording over time, a number of experimental details will come to the surface when listened to carefully. “We tried everything,” lists Tipton. “At Judas Priest, we’ve always been willing to experiment, and we’ve always tried to push the boundaries of metal to make it more bearable. That’s why people may have called us metal ambassadors.” And so, instead of a whip, it sounds like a string swinging on the kitchen counter, instead of a police siren, a guitar and stomping metal monsters in “Metal Gods” have replaced cutlery drawers. Methods that nowadays, full of samples from the Internet, seem comically woody.

It is worth asking to what extent the sound and the experimental nature of the work were influenced by the place where it originated. The original studio disappointed, so the group rented a country house in Tittenhurst Park to shoot. It belonged to The Beatles drummer Ringo Starr, who bought it from John Lennon. However, it didn’t look the best at first and the band decided to literally play the whole house.

“We started preparing the studio,” describes producer Tom Allom, “But it was quite small and everything sounded flat. We soon realized that we were not able to achieve the desired sound, so we decided, knowing that it would make communication between the control room and the musicians difficult, use the space of the whole house.”

Bassist Ian Hill adds: “We had the advantage that there were dozens of rooms and you could stick wires everywhere in the socket. You could easily record the guitar in the bathroom. Each room had a different acoustics. So you had a variety of sound palettes to choose from.”

The concentrated heavy metal essence hit the time well. Punk was at the zenith, and some of the youth who refused to play synth-pop immediately clapped after “British Steel”. For Judas Priest, the golden age began, when the months spent on tour alternated with time in the studio. More great records were waiting for them, but the influence of this one the purest British steel is by far the largest.

“It’s absolutely beautiful that Judas Priest has become the godfather of modern heavy metal,” the second guitarist KK Downing does not hide his enthusiasm. And singer Rob Halford adds: “The album ‘British Steel’, given its importance, is a universal key that unlocks all the other doors. It’s wonderful that Judas Priest’s legacy remains intact. It’s still a very important band with something to say and a massive fan base. Worldwide.”

A detailed look at the shooting of “British Steel” and spicy stories from behind the scenes was brought by another part of the Famous Albums series. On Friday, October 29, it was broadcast by ?T art. For a week, the cycle continues with the story of Frank Zappa’s “Apostrophe” and “Over-Nite Sensation”.

A series of articles is created in cooperation with Czech Television.

We would like to say thanks to the author of this write-up for this amazing content

FAMOUS ALBUM: In the heavy metal kitchen Judas Priest cooked “British Steel”, a work that kicked off their career and became a role model

[date_timestamp] => 1635578500 ) [9] => Array ( [title] => The day life ends on Earth [link] => https://bofads.com/the-day-life-ends-on-earth/ [dc] => Array ( [creator] => Paula Hooper ) [pubdate] => Sat, 30 Oct 2021 07:18:53 +0000 [category] => SciencesdayEarthLife [guid] => https://bofads.com/?p=765 [description] => By Pierre Barthélémy Posted on April 12, 2021 at 6:30 p.m. – Updated on April 13, 2021 at 6:20 a.m. Reserved for our subscribers DecryptionCO2? Not too much need. But in about a billion years, its disappearance from the atmosphere, caused by the aging of the Sun, will lead to the extinction of living things ... Read more [content] => Array ( [encoded] =>
By Pierre Barthélémy

Posted on April 12, 2021 at 6:30 p.m. – Updated on April 13, 2021 at 6:20 a.m.

Let’s face it, the news from planet Earth is hardly encouraging: a pandemic still not under control that will kill millions of people, a global warming that we are slow to fight while it turns ecosystems upside down and weakens entire populations, an accelerated erosion of biodiversity? Yet, with hindsight, it can be said without cynicism that, despite all this, life will continue, even if we eradicate ourselves in a thermonuclear Armageddon.

Life will continue as it did after each of the five great extinctions that have punctuated the last 500 million years and each time wiped out more than three quarters of species. Yes, life, stubborn, ingenious, resilient, will continue … Until the day when the physico-chemical conditions on the surface of our globe will force it to surrender.

An eschatological story, the description of the long journey towards this day of hell or nothingness, is what contains an article published in early March in Nature Geoscience and signed by the Japanese Kazumi Ozaki (Toho University, Funabashi) and the American Christopher Reinhard (Georgia Institute of Technology).

It examines the evolution of the presence of oxygen in the atmosphere. This molecule has not always been present on Earth: ?At the beginning of our planet’s history, the atmosphere was very rich in CO2, recalls Benjamin Charnay, researcher at the CNRS, specialist in the atmosphere of the primitive Earth and that of exoplanets. It’s in this oxygen-free environment that life originated just over 3.8 billion years ago as single-celled organisms, some of which were expected to produce methane. “

The “snowball” effect of oxygen

?Oxygenic photosynthesis appeared between ? 3 billion and ? 2.7 billion years, continues Benjamin Charnay. It uses light to form biomass from carbon dioxide and it is a much more efficient mechanism for this than that of methanogenic organisms. ” As we learn in college, photosynthesis allows the beings who use it to capture the carbon atom of CO2 and release the oxygen we breathe.

“Atmospheric oxygen is a product of biology, underlines Purificacion Lopez-Garcia, research director at CNRS and specialist in microbial evolution. It was first produced by cyanobacteria and all current oxygenic photosynthesis derives from them. Chloroplasts, organelles responsible for photosynthesis in plants, are the derivatives of these ancient bacteria. ” During a process called endosymbiosis, algae and plants have somehow ingested and integrated cyanobacteria to join their services.

You have 76.71% of this article to read. The rest is for subscribers only.

We would like to say thanks to the writer of this post for this outstanding content

The day life ends on Earth

) [summary] => By Pierre Barthélémy Posted on April 12, 2021 at 6:30 p.m. – Updated on April 13, 2021 at 6:20 a.m. Reserved for our subscribers DecryptionCO2? Not too much need. But in about a billion years, its disappearance from the atmosphere, caused by the aging of the Sun, will lead to the extinction of living things ... Read more [atom_content] =>
By Pierre Barthélémy

Posted on April 12, 2021 at 6:30 p.m. – Updated on April 13, 2021 at 6:20 a.m.

Let’s face it, the news from planet Earth is hardly encouraging: a pandemic still not under control that will kill millions of people, a global warming that we are slow to fight while it turns ecosystems upside down and weakens entire populations, an accelerated erosion of biodiversity? Yet, with hindsight, it can be said without cynicism that, despite all this, life will continue, even if we eradicate ourselves in a thermonuclear Armageddon.

Life will continue as it did after each of the five great extinctions that have punctuated the last 500 million years and each time wiped out more than three quarters of species. Yes, life, stubborn, ingenious, resilient, will continue … Until the day when the physico-chemical conditions on the surface of our globe will force it to surrender.

An eschatological story, the description of the long journey towards this day of hell or nothingness, is what contains an article published in early March in Nature Geoscience and signed by the Japanese Kazumi Ozaki (Toho University, Funabashi) and the American Christopher Reinhard (Georgia Institute of Technology).

It examines the evolution of the presence of oxygen in the atmosphere. This molecule has not always been present on Earth: ?At the beginning of our planet’s history, the atmosphere was very rich in CO2, recalls Benjamin Charnay, researcher at the CNRS, specialist in the atmosphere of the primitive Earth and that of exoplanets. It’s in this oxygen-free environment that life originated just over 3.8 billion years ago as single-celled organisms, some of which were expected to produce methane. “

The “snowball” effect of oxygen

?Oxygenic photosynthesis appeared between ? 3 billion and ? 2.7 billion years, continues Benjamin Charnay. It uses light to form biomass from carbon dioxide and it is a much more efficient mechanism for this than that of methanogenic organisms. ” As we learn in college, photosynthesis allows the beings who use it to capture the carbon atom of CO2 and release the oxygen we breathe.

“Atmospheric oxygen is a product of biology, underlines Purificacion Lopez-Garcia, research director at CNRS and specialist in microbial evolution. It was first produced by cyanobacteria and all current oxygenic photosynthesis derives from them. Chloroplasts, organelles responsible for photosynthesis in plants, are the derivatives of these ancient bacteria. ” During a process called endosymbiosis, algae and plants have somehow ingested and integrated cyanobacteria to join their services.

You have 76.71% of this article to read. The rest is for subscribers only.

We would like to say thanks to the writer of this post for this outstanding content

The day life ends on Earth

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